Recently, the use of the antiepileptic drug valproic acid (VPA) for the treatment of psychiatric conditions has been on the rise. However, studies have shown that in utero VPA exposure can affect embryonic development, including being associated with congenital heart defects. One proposed mechanism of VPA‐initiated teratogenicity is the inhibition of histone deacetylase, which is involved in the regulation of transcription factors that regulate cardiogenesis. Myocyte enhancing factor 2C (Mef2c), a transcription factor involved in the development of cardiac structure and cardiomyocyte differentiation, has been shown to increase in response to in utero VPA exposure, associating with contractile dysfunction and myocardial disorganization.

中文翻译：

---

表征子宫内丙戊酸暴露对小鼠胎儿心脏发育的影响。

近来，抗癫痫药丙戊酸（VPA）用于治疗精神疾病的用途正在增加。但是，研究表明，子宫内VPA暴露会影响胚胎发育，包括与先天性心脏缺陷有关。VPA引发致畸性的一种建议机制是抑制组蛋白脱乙酰基酶，该酶参与调节调节心脏发生的转录因子。心肌细胞增强因子2C（Mef2c）是参与心脏结构发展和心肌细胞分化的转录因子，已显示出对子宫内VPA暴露的反应会增加，这与收缩功能障碍和心肌紊乱有关。