The use of natural products from herbs may be a therapeutic option in dyslipidemia treatment. Campomanesia xanthocarpa (Mart.) O. Berg (Myrtaceae) leaves have been used to decrease cholesterol levels. However, studies to determine activities of this plant on triglycerides metabolism have received little attention. The aim of this study was to examine anti-hyperlipidemic effects of a C. xanthocarpa aqueous leaf extract (CxAE) and assess protective actions against oxidative stress and DNA damage. The tyloxapol-induced hyperlipidemia model was used in Wistar rats. Rats were treated orally with CxAE either 250 or 500 mg/kg/day for 7 days prior to tyloxapol administration. Biochemical parameters, oxidative stress levels, and genomic instability were assessed in several tissues. CxAE decreased cholesterol and triglyceride levels in serum and hepatic and renal DNA damage in tyloxapol-treated rats. There was no marked effect on the micronucleus frequency in bone marrow. The extract increased catalase activity and decreased glutathione S-transferase activity in kidney tissue. CxAE showed anti-hyperlipidemic effects, improved oxidative parameters, and protected DNA against damage induced by tyloxapol-induced hyperlipidemia, suggesting C. xanthocarpa leaves may be useful in preventing dyslipidemias.Abbreviations: ALP: Alkaline phosphatase; ALT: Aspartate aminotransferase; ANOVA: Analysis of variance; AST: Aspartate aminotransferase; Ator: Atorvastatin; CAT: Catalase; Chol: Cholesterol; CxAE: Campomanesia xanthocarpa aqueous extract; GST: Glutathione S-transferase; HDL: High density cholesterol; i.p.: Intraperitoneal; NCE: Normochromatic erythrocyte; PBS: Phosphate buffer solution; PCE: Polychromatic erythrocyte; ROS: Reactive oxygen species; SD: Standard deviation; SOD: Superoxide dismutase; T: Tyloxapol; TBARS: Thiobarbituric acid reacting substances; TG: Triglyceride.

中文翻译：

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桔梗桔梗水提取物的抗高脂血症作用及其​​对Wistar大鼠氧化应激和基因组不稳定的调节作用。

来自草药的天然产物的使用可能是血脂异常治疗的治疗选择。桔梗（Martoma）O。Berg（桃金娘科）的叶子已被用于降低胆固醇水平。然而，确定这种植物对甘油三酸酯代谢活性的研究很少受到关注。这项研究的目的是检查角果衣原含水叶提取物（CxAE）的抗高血脂作用，并评估其对氧化应激和DNA损伤的保护作用。泰洛沙泊诱导的高脂血症模型用于Wistar大鼠。在给予替洛沙泊之前，将大鼠口服CxAE 250或500 mg / kg /天治疗7天。在几个组织中评估了生化参数，氧化应激水平和基因组不稳定性。CxAE降低了替洛沙泊治疗的大鼠的血清胆固醇和甘油三酸酯水平以及肝和肾DNA损伤。对骨髓中的微核频率没有明显影响。提取物增加了肾脏组织中的过氧化氢酶活性，并降低了谷胱甘肽S-转移酶活性。CxAE表现出抗高血脂作用，改善的氧化参数并保护DNA免受泰洛沙泊诱导的高脂血症所致的损害，这表明角果衣原叶可用于预防血脂异常。ALT：天冬氨酸转氨酶；方差分析：方差分析；AST：天冬氨酸转氨酶；阿托尔：阿托伐他汀；CAT：过氧化氢酶；胆固醇：胆固醇；CxAE：桔梗黄果提取物；GST：谷胱甘肽S-转移酶；HDL：高密度胆固醇；ip：腹膜内；NCE：正常色红细胞；PBS：磷酸盐缓冲液；PCE：多色红细胞；ROS：活性氧；SD：标准偏差；SOD：超氧化物歧化酶；T：泰洛沙泊；TBARS：硫代巴比妥酸反应物质；TG：甘油三酸酯。