Fengycins are compounds produced by bacteria of the Bacillus genus with strong antifungal activity. In this work, lipids extracted from fungal and oomycetal molds were used to assess the ability of fengycin to bind and insert into complex membrane models prepared as Langmuir lipid monolayers. In addition, fengycin-induced leakage in liposomes prepared from these complex lipid extracts was also evaluated. Fengycin's ability to bind and incorporate into these membranes seemed to be mainly related to ergosterol content. Other membrane characteristics such as phospholipid fatty acyl chain length played a more peripheral role. A high ergosterol concentration appeared to allow other membrane characteristics generally associated with fengycin binding and/or insertion, such as higher proportion of phosphatidylcholine head groups or increased fatty acyl unsaturation, to be present without adversely affecting membrane integrity. Increased membrane leakage was also generally associated with the presence of low or no ergosterol. Leakage was also correlated with the previously reported biological activity of fengycin on these molds.

中文翻译：

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脂质成分在抗菌化合物丰霉素与复杂膜模型的相互作用和活性中的作用。

丰霉素是由芽孢杆菌属细菌产生的具有强抗真菌活性的化合物。在这项工作中，从真菌和卵菌模中提取的脂质用于评估风霉素结合并插入制备为Langmuir脂质单层的复杂膜模型中的能力。另外，还评估了由风霉素引起的由这些复合脂质提取物制备的脂质体的渗漏。丰霉素结合并结合到这些膜中的能力似乎主要与麦角固醇含量有关。其他膜特性，例如磷脂脂肪酰基链长，起着更重要的作用。较高的麦角固醇浓度似乎可以使通常与丰霉素结合和/或插入有关的其他膜特性，例如存在较高比例的磷脂酰胆碱头基或增加的脂肪酰基不饱和度，而不会不利地影响膜的完整性。膜泄漏增加通常也与麦角固醇含量低或无麦角甾醇有关。泄漏还与以前报道的丰霉素在这些霉菌上的生物活性有关。