Skeleton undergoes constant remodeling process to maintain healthy bone mass. However, in pathological conditions, bone remodeling is deregulated, resulting in unbalanced bone resorption and formation. Abnormal osteoclast formation and activation play a key role in osteolysis, such as in rheumatoid arthritis and osteoporosis. As potential therapeutic targets or biomarkers, miRNAs have gained rapidly growing research and clinical attention. miRNA-based therapeutics is recently entering a new era for disease treatment. Such progress is emerging in treatment of skeletal diseases. In this review, we discuss miRNA biogenesis, advances in the strategies for miRNA target identification, important miRNAs involved in osteoclastogenesis and disease models, their regulated mechanisms, and translational potential and challenges in bone homeostasis and related diseases.

中文翻译：

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破骨细胞microRNA及其在骨骼疾病中的翻译潜力。

骨骼经过不断的重塑过程以维持健康的骨骼质量。但是，在病理情况下，骨骼重塑失调，导致骨骼吸收和形成不平衡。破骨细胞的异常形成和激活在骨溶解中起关键作用，例如在类风湿性关节炎和骨质疏松症中。作为潜在的治疗靶标或生物标志物，miRNA已获得快速增长的研究和临床关注。基于miRNA的疗法最近进入了疾病治疗的新时代。这样的进展在骨骼疾病的治疗中正在出现。在这篇综述中，我们讨论了miRNA的生物发生，miRNA靶标鉴定策略的进展，参与破骨细胞形成和疾病模型的重要miRNA及其调控机制，