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Fractional anisotropy of the optic radiations correlates with the visual field after epilepsy surgery.
Neuroradiology ( IF 2.4 ) Pub Date : 2019-09-07 , DOI: 10.1007/s00234-019-02281-2
João Paulo Sant Ana Santos de Souza 1 , Gabriel Ayub 2 , Pamela Castro Pereira 1 , José Paulo Cabral Vasconcellos 2 , Clarissa Yasuda 1, 3 , Andrei Fernandes Joaquim 3 , Helder Tedeschi 3 , Brunno Machado Campos 1 , Fernando Cendes 1, 3 , Enrico Ghizoni 3
Affiliation  

PURPOSE This study assessed whether optic radiations (OR) microstructure after temporal lobe epilepsy (TLE) surgery correlated with visual field defects (VFD). METHODS Patients were subjected to diffusion tensor imaging (DTI) tractography of the OR and Humphrey perimetry after TLE surgery. We used Spearman's test to verify correlations between tractographic parameters and perimetry mean deviation. Tractographic variables were compared between patients with VFD or intact perimetry. Multiple logistic regression was applied between DTI and perimetry values. DTI sensitivity and specificity were assessed with a receiver operating characteristic (ROC) curve to evaluate VFD. RESULTS Thirty-nine patients had reliable perimetry and OR tractography. There was a significant correlation between (1) fractional anisotropy (FA) and both total (rho = 0.569, p = 0.0002) and quadrant (rho = 0.453, p = 0.0037) mean deviation and (2) radial diffusivity and total mean deviation (rho = - 0.350, p = 0.0286). There was no other significant correlation. Patients with VFD showed a significantly lower FA compared with patients with normal perimetry (p = 0.0055), and a 0.01 reduction in FA was associated with a 44% increase in presenting VFD after surgery (confidence interval, CI = 1.10-1.88; p = 0.0082). Using a FA of 0.457, DTI tractography showed a specificity of 95.2% and a sensitivity of 50% to detect VFD after surgery (area under the curve = 0.7619, CI = 0.6020-0.9218). CONCLUSION The postoperative OR microstructure correlated with visual loss after epilepsy surgery. DTI postoperative OR tractography may be helpful in evaluating VFD.

中文翻译:

癫痫手术后,视线辐射的分数各向异性与视野相关。

目的本研究评估颞叶癫痫(TLE)手术后的视辐射(OR)微观结构是否与视野缺损(VFD)相关。方法对患者进行TLE手术后的OR和Humphrey视野检查的弥散张量成像(DTI)显像。我们使用Spearman's检验来验证束线图参数与视野测定术平均偏差之间的相关性。比较了具有VFD或完整视野检查的患者之间的术式变量。在DTI和视野测量值之间应用了多元逻辑回归。DTI敏感性和特异性用接收器工作特征(ROC)曲线评估,以评估VFD。结果39例患者具有可靠的视野检查和OR显像。(1)分数各向异性(FA)与两者的总和之间存在显着相关性(rho = 0.569,p = 0.0002)和象限(rho = 0.453,p = 0.0037)平均偏差以及(2)径向扩散率和总平均偏差(rho =-0.350,p = 0.0286)。没有其他显着相关性。与正常视野检查的患者相比,VFD患者的FA显着降低(p = 0.0055),FA降低0.01与术后出现VFD的患者增加44%(置信区间,CI = 1.10-1.88; p = 0.0082)。使用0.457的FA时,DTI体层摄影术显示出在手术后检测VFD的特异性为95.2%,灵敏度为50%(曲线下面积= 0.7619,CI = 0.6020-0.9218)。结论癫痫手术后的手术后微结构与视力丧失有关。术后进行DTI或放射线描记可能有助于评估VFD。0037)平均偏差和(2)径向扩散率和总平均偏差(rho =-0.350,p = 0.0286)。没有其他显着相关性。与正常视野检查的患者相比,VFD患者的FA显着降低(p = 0.0055),FA降低0.01与术后出现VFD的患者增加44%(置信区间,CI = 1.10-1.88; p = 0.0082)。使用0.457的FA时,DTI体层摄影术显示出在手术后检测VFD的特异性为95.2%,灵敏度为50%(曲线下面积= 0.7619,CI = 0.6020-0.9218)。结论癫痫手术后的手术后微结构与视力丧失有关。术后进行DTI或放射线描记可能有助于评估VFD。0037)平均偏差和(2)径向扩散率和总平均偏差(rho =-0.350,p = 0.0286)。没有其他显着相关性。与正常视野检查的患者相比,VFD患者的FA显着降低(p = 0.0055),FA降低0.01与术后出现VFD的患者增加44%(置信区间,CI = 1.10-1.88; p = 0.0082)。使用0.457的FA时,DTI体层摄影术显示出在手术后检测VFD的特异性为95.2%,灵敏度为50%(曲线下面积= 0.7619,CI = 0.6020-0.9218)。结论癫痫手术后的手术后微结构与视力丧失有关。术后进行DTI或放射线描记可能有助于评估VFD。与正常视野检查的患者相比,VFD患者的FA显着降低(p = 0.0055),FA降低0.01与术后出现VFD的患者增加44%(置信区间,CI = 1.10-1.88; p = 0.0082)。使用0.457的FA时,DTI体层摄影术显示出在手术后检测VFD的特异性为95.2%,灵敏度为50%(曲线下面积= 0.7619,CI = 0.6020-0.9218)。结论癫痫手术后手术后的微结构与视力丧失有关。术后进行DTI或放射线描记可能有助于评估VFD。与正常视野检查的患者相比,VFD患者的FA显着降低(p = 0.0055),FA降低0.01与术后出现VFD的患者增加44%(置信区间,CI = 1.10-1.88; p = 0.0082)。使用0.457的FA时,DTI体层摄影术显示出在手术后检测VFD的特异性为95.2%,灵敏度为50%(曲线下面积= 0.7619,CI = 0.6020-0.9218)。结论癫痫手术后的手术后微结构与视力丧失有关。术后进行DTI或放射线描记可能有助于评估VFD。使用0.457的FA时,DTI体层摄影术显示出在手术后检测VFD的特异性为95.2%,灵敏度为50%(曲线下面积= 0.7619,CI = 0.6020-0.9218)。结论癫痫手术后手术后的微结构与视力丧失有关。术后进行DTI或放射线描记可能有助于评估VFD。使用0.457的FA时,DTI体层摄影术显示出在手术后检测VFD的特异性为95.2%,灵敏度为50%(曲线下面积= 0.7619,CI = 0.6020-0.9218)。结论癫痫手术后手术后的微结构与视力丧失有关。术后进行DTI或放射线描记可能有助于评估VFD。
更新日期:2019-09-07
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