Metabolic dysregulation is an appreciated hallmark of cancer and a target for therapeutic intervention. Cellular metabolism involves a series of oxidation/reduction (redox) reactions that yield the energy and biomass required for tumor growth. Cells require diverse molecular species with constituent sulfur atoms to facilitate these processes. For humans, this sulfur is derived from the dietary consumption of the proteinogenic amino acids cysteine and methionine, as only lower organisms (e.g., bacteria, fungi, and plants) can synthesize them de novo. In addition to providing the sulfur required to sustain redox chemistry, the metabolism of these sulfur-containing amino acids yield intermediate metabolites that constitute the cellular antioxidant system, mediate inter- and intracellular signaling, and facilitate the epigenetic regulation of gene expression, all of which contribute to tumorigenesis.

中文翻译：

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硫代谢及其对恶性肿瘤的作用。

代谢失调是癌症的公认标志，也是治疗干预的目标。细胞代谢涉及一系列氧化/还原（redox）反应，产生肿瘤生长所需的能量和生物量。细胞需要具有组成硫原子的多种分子，以促进这些过程。对于人类而言，这种硫来自饮食中半胱氨酸和蛋氨酸的蛋白质来源的饮食，因为只有低等生物（例如细菌，真菌和植物）才能从头合成它们。除了提供维持氧化还原化学所需的硫以外，这些含硫氨基酸的代谢还产生构成细胞抗氧化剂系统，介导细胞内和细胞内信号转导的中间代谢物，