Dietary fat is digested and absorbed in the small intestine and can then be utilized as an energy source and/or as a reservoir for other bioactive lipid species. Excessive dietary fat has been implicated in the induction and/or aggravation of several diseases, including colorectal cancer (CRC). Diets with high fat content have been shown to exacerbate CRC through regulation of intestinal inflammation and proliferation, as well as alteration of bile acid pools, microbiota, and bioactive lipid species. This chapter will investigate the effects of dietary fat on CRC development and pathobiology, and possible mechanisms for specific lipid species in those processes.

中文翻译：

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饮食，脂质和结肠癌。

膳食脂肪在小肠中被消化吸收，然后可以用作能量来源和/或用作其他生物活性脂质种类的储存库。饮食中过量的脂肪与多种疾病的诱发和/或恶化有关，包括结直肠癌（CRC）。高脂饮食已显示出通过调节肠内炎症和增殖以及改变胆汁酸库，微生物群和生物活性脂质种类而加重CRC的能力。本章将研究膳食脂肪对CRC发育和病理生物学的影响，以及这些过程中特定脂质种类的可能机制。