ABSTRACT This study was conducted to assess the effects of the hydroxy-analogue of selenomethionine (HMSeBA) on growth performance, selenium (Se) deposition and antioxidant status of piglets. In a 28-d experiment, 252 piglets were assigned into seven treatments. These treatments were a negative control (Con-, basal diet without supplement Se), a positive control (Con+, basal diet + 0.3 mg Se from sodium selenite per kg), and five HMSeBA groups (basal diet + 0.1, 0.2, 0.3, 0.4 and 0.5 mg Se/kg from HMSeBA, respectively). Results showed that dietary HMSeBA supplementation did not affect growth performance of piglets. However, HMSeBA supplementation increased the Se concentrations in serum, liver, kidney and muscle compared with groups Con- and Con+ (p < 0.05). Compared with group Con-, supplementation with 0.2 and 0.4 mg Se from HMSeBA increased serum total antioxidant capability (T-AOC) and addition of 0.4 and 0.5 mg Se from HMSeBA increased serum glutathione peroxidase (GSH-Px) activities (p < 0.05). Compared with group Con-, the addition of 0.1, 0.2, 0.4, 0.5 mg Se from HMSeBA increased GSH-Px activities and decreased malondialdehyde (MDA) contents in the liver, and 0.3 mg Se from HMSeBA increased T-AOC and GSH-Px activities in the liver (p < 0.05). Compared with group Con+, 0.3 mg Se from HMSeBA increased serum superoxide dismutase (SOD) and hepatic T-AOC activities, and decreased the serum MDA level (p < 0.05). In general, dietary HMSeBA supplementation could improve Se deposition in serum and tissue and antioxidant capacity of piglets, suggesting that HMSeBA could be an effective Se source for piglets.

中文翻译：

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日粮中不同水平的硒代蛋氨酸羟基类似物对断奶仔猪生长性能、硒沉积和抗氧化状态的影响

摘要 本研究旨在评估硒代蛋氨酸的羟基类似物 (HMSeBA) 对仔猪生长性能、硒 (Se) 沉积和抗氧化状态的影响。在一个为期 28 天的实验中，252 头仔猪被分配到七个处理中。这些处理是阴性对照（Con-，无补充硒的基础饮食）、阳性对照（Con+，基础饮食 + 0.3 mg Se 亚硒酸钠/kg）和五个 HMSeBA 组（基础饮食 + 0.1、0.2、0.3、 0.4 和 0.5 mg Se/kg，分别来自 HMSeBA）。结果表明，日粮中添加 HMSeBA 不会影响仔猪的生长性能。然而，与 Con- 和 Con+ 组相比，HMSeBA 补充剂增加了血清、肝脏、肾脏和肌肉中的硒浓度（p < 0.05）。与Con-组相比，补充0.2和0。来自 HMSeBA 的 4 毫克硒增加了血清总抗氧化能力 (T-AOC)，并且添加了来自 HMSeBA 的 0.4 和 0.5 毫克硒增加了血清谷胱甘肽过氧化物酶 (GSH-Px) 活性 (p < 0.05)。与Con-组相比，HMSeBA添加0.1、0.2、0.4、0.5 mg Se可提高肝脏中GSH-Px活性并降低丙二醛(MDA)含量，HMSeBA添加0.3 mg Se可提高T-AOC和GSH-Px肝脏活动（p < 0.05）。与 Con+ 组相比，来自 HMSeBA 的 0.3 mg Se 增加了血清超氧化物歧化酶 (SOD) 和肝脏 T-AOC 活性，并降低了血清 MDA 水平（p < 0.05）。总的来说，日粮中添加 HMSeBA 可以改善仔猪血清和组织中硒的沉积以及抗氧化能力，表明 HMSeBA 可能是仔猪的有效硒来源。