Germline CDH1 mutation carriers are at risk for early-onset diffuse gastric cancer (DGC) and female carriers have an additional risk of lobular breast cancer. The reported literature GC risk of 70% has led to the recommendation for germline mutation carriers to undergo prophylactic total gastrectomy (PTG). The objective of this research was to examine post-surgical clinical outcomes and to identify which of the domains/symptoms from the European Organisation for Research and Treatment of Cancer QOL Questionnaire (EORTC QLQ-C30) were determinants of overall quality of life (QOL) in individuals undergoing PTG. Participants were recruited through multiple sources. Postsurgical clinical outcomes were obtained from hospital records. Participants completed validated questionnaires measuring generic and condition specific QOL (PROMIS, EORTC and SF 36v.II) at a single point in time. The mean QOL in this cohort was 70.6 (SD = 25.6), which is better than reference values from the general populations in USA and Canada Role and social function plus the symptoms anxiety, pain, taste, dyspnea and diarrhea were significant predictor variables for QOL (p < 0.05). Although this study reveals good overall QOL for individuals after PTG, attention should be given to managing symptoms as part of long term care to further enhance QOL. The function/symptom scores were associated with worse overall health and global health status and thus may mark a real need for more attentive post-surgical care.

中文翻译：

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遗传性弥漫性胃癌：癌症风险和预防性手术的个人费用。

胚芽CDH1突变携带者有罹患早发性弥漫性胃癌（DGC）的风险，而女性携带者则具有小叶性乳腺癌的额外风险。文献报道的GC风险为70％，因此建议对种系突变携带者进行预防性全胃切除术（PTG）。这项研究的目的是检查手术后的临床结局并确定来自欧洲癌症研究和治疗组织QOL调查表（EORTC QLQ-C30）的哪些领域/症状是总体生活质量（QOL）的决定因素在经历PTG的个体中。参与者是通过多种渠道招募的。手术后的临床结果来自医院的记录。参与者完成了验证的问卷，这些问卷测量了通用和特定条件的QOL（PROMIS，EORTC和SF 36v。II）在单个时间点。该队列的平均QOL为70.6（SD = 25.6），优于美国和加拿大普通人群的参考值。角色和社会功能以及症状焦虑，疼痛，味觉，呼吸困难和腹泻是QOL的重要预测变量（p ＜0.05）。尽管这项研究显示PTG后个体的总体QOL良好，但应注意管理症状，作为进一步提高QOL的长期护理的一部分。功能/症状评分与总体健康状况和整体健康状况恶化相关，因此可能标志着对更细心的术后护理的真正需求。呼吸困难和腹泻是生活质量的重要预测变量（p <0.05）。尽管这项研究显示PTG后个体的总体QOL良好，但应注意管理症状，作为进一步提高QOL的长期护理的一部分。功能/症状评分与总体健康状况和整体健康状况恶化相关，因此可能标志着对更细心的术后护理的真正需求。呼吸困难和腹泻是生活质量的重要预测变量（p <0.05）。尽管这项研究显示PTG后个体的总体QOL良好，但应注意管理症状，这是进一步提高QOL的长期护理的一部分。功能/症状评分与总体健康状况和整体健康状况恶化相关，因此可能标志着对更细心的术后护理的真正需求。