The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs offers a paradigm shift in regenerative medicine. The use of either embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) in clinical situations is limited because of regulations and ethical considerations even though these cells are theoretically highly beneficial. While clinically, adipose-derived stem cells (ADSCs) are one of the most widely used types of stem cells used more than five years in clinically setting. It has many advantages including; yields a high number of ADSCs per volume of tissue, high rate of proliferation, anti-fibrotic, anti-apoptotic, anti-inflammation, immunomodulation, and paracrine mechanisms have been demonstrated in various preclinical studies. It is much easier to harvest compared with bone marrow stem cells. Results of clinical studies have demonstrated the potentials of ADSCs for stem cells therapy for a number of clinical disorders. The aim of this paper was to provide an update on the most recent developments of ADSCs, by highlighting the properties and features of ADSCs, critically discussing its clinical benefit and its clinical trials in treatment and regeneration. This is a multi-billion dollars industry with huge interest to clinician, academia and industries.

中文翻译：

---

具有巨大治疗潜力的人脂肪干细胞。

基于干细胞的疗法在各种组织和器官的修复和再生中的潜在用途为再生医学提供了范式转变。由于法规和道德方面的考虑，即使在理论上高度有益，但由于法规和道德考虑，在临床情况下限制使用胚胎干细胞（ESC）或诱导多能干细胞（iPSC）。在临床上，脂肪干细胞（ADSCs）是临床上使用五年以上的最广泛使用的干细胞类型之一。它具有许多优点，包括；在各种临床前研究中已证明，每单位体积的组织会产生大量的ADSC，具有较高的增殖率，抗纤维化，抗凋亡，抗炎症，免疫调节和旁分泌机制。与骨髓干细胞相比，它更容易收获。临床研究结果表明，ADSCs可用于多种临床疾病的干细胞治疗。本文的目的是通过重点介绍ADSC的特性和特征，批判性地讨论其临床益处以及在治疗和再生方面的临床试验，来提供有关ADSC的最新进展的最新信息。这是一个价值数十亿美元的行业，临床医生，学术界和行业都对此产生了浓厚的兴趣。严格讨论其临床益处以及在治疗和再生方面的临床试验。这是一个价值数十亿美元的行业，临床医生，学术界和行业都对此感兴趣。严格讨论其临床益处以及在治疗和再生方面的临床试验。这是一个价值数十亿美元的行业，临床医生，学术界和行业都对此感兴趣。