The objective of this study was to determine the effects of sanshoamides and capsaiciniods on plasma and liver lipid levels and the mRNA expression levels of key receptors involved in cholesterol metabolism in hyperlipidemic rats. A total of 56 three-week-old female Sprague-Dawley rats were assigned to 7 treatment groups based on initial body weight (n = 8 rats per group). With certain combinations of sanshoamides and capsaicinoids significantly increased food intake, reduced lipid levels in blood and liver, improved histological characteristics of a fatty liver, down regulated mRNA expression levels of cholesterol 7-alpha-hydroxylase (CYP7A1), 3-hydroxyl-3-methylglutary CoA (HMG-CoA) and Farnesoid X Receptor (FXR) in liver and apical sodium-dependent bile acid transporter, Ileal Bile Acid Binding Protein and FXR in the ileum in hyperlipidemic rats. These results indicated that dietary supplementation with sanshoamides and capsaicinoids reduced blood lipid levels and improved cholesterol metabolism in hyperlipidemic rats.

中文翻译：

---

Sanshoamides和辣椒素类化合物对高脂血症大鼠血浆和肝脂质代谢的影响。

这项研究的目的是确定sanshoamides和辣椒素对高脂血症大鼠血浆和肝脂质水平以及参与胆固醇代谢的关键受体的mRNA表达水平的影响。根据初始体重，将总共56只三周大的Sprague-Dawley雌性大鼠分为7个治疗组（每组n = 8只大鼠）。结合使用Sanshoamide和辣椒素类化合物可显着增加食物摄入量，降低血液和肝脏中的脂质水平，改善脂肪肝的组织学特征，下调胆固醇7-α-羟化酶（CYP7A1），3-羟化-3-肝脏和心尖钠依赖性胆汁酸转运蛋白中的甲基戊二酰辅酶A（HMG-CoA）和法呢素X受体（FXR），高脂血症大鼠回肠中的回肠胆汁酸结合蛋白和FXR。这些结果表明，在高脂血症大鼠中，饮食中补充三樟酰胺和辣椒素类物质可降低血脂水平并改善胆固醇代谢。