Glucagon‐like peptide‐1 (GLP‐1) is a type of incretin secreted from enteroendocrine L‐cells. Our previous studies demonstrated that curcumin (a yellow pigment of turmeric) significantly increases the secretion of GLP‐1 in enteroendocrine L cell line (GLUTag cells). However, it is not clear whether its action in vivo directly enhances GLP‐1 secretion, which then leads to a reduction in blood glucose levels via the stimulation of insulin secretion. In addition, the molecular target of curcumin‐induced GLP‐1 secretion has not been clarified.

中文翻译：

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姜黄素通过刺激胰高血糖素样肽1分泌改善葡萄糖耐量。

胰高血糖素样肽-1（GLP-1）是肠内分泌L细胞分泌的一种肠降血糖素。我们以前的研究表明姜黄素（姜黄的黄色素）显着增加了肠内分泌L细胞系（GLUTag细胞）中GLP-1的分泌。然而，尚不清楚其在体内的作用是否直接增强了GLP-1的分泌，然后通过刺激胰岛素分泌而导致血糖​​水平降低。此外，姜黄素诱导的GLP-1分泌的分子靶点尚不清楚。