Youth with bipolar disorder (BD) and those with severe, non-episodic irritability (severe mood dysregulation, SMD) show face-emotion labeling deficits. These groups differ from healthy volunteers (HV) in neural responses to emotional faces. It is unknown whether awareness is required to elicit these differences. We compared activation in BD (N = 20), SMD (N = 18), and HV (N = 22) during “Aware” and “Non-aware” priming of shapes by emotional faces. Subjects rated how much they liked the shape. In aware, a face (angry, fearful, happy, neutral, blank oval) appeared (187 ms) before the shape. In non-aware, a face appeared (17 ms), followed by a mask (170 ms), and shape. A Diagnosis-by-Awareness-by-Emotion ANOVA was not significant. There were significant Diagnosis-by-Awareness interactions in occipital regions. BD and SMD showed increased activity for non-aware vs. aware; HV showed the reverse pattern. When subjects viewed angry or neutral faces, there were Emotion-by-Diagnosis interactions in face-emotion processing regions, including the L precentral gyrus, R posterior cingulate, R superior temporal gyrus, R middle occipital gyrus, and L medial frontal gyrus. Regardless of awareness, BD and SMD differ in activation patterns from HV and each other in multiple brain regions, suggesting that BD and SMD are distinct developmental mood disorders.

患有双相情感障碍 (BD) 的青少年和患有严重的非发作性易怒症（严重情绪失调，SMD）的青少年表现出面部情绪标签缺陷。这些群体在对情绪面孔的神经反应方面与健康志愿者 (HV) 不同。尚不清楚是否需要意识来引发这些差异。我们比较了 BD ( N = 20)、SMD ( N = 18) 和 HV ( N= 22) 在“有意识”和“无意识”通过情绪面孔启动形状期间。受试者评价他们喜欢这个形状的程度。有意识地，在形状之前（187 毫秒）出现了一张脸（愤怒、恐惧、快乐、中性、空白椭圆）。在无意识中，出现了一张脸（17 毫秒），然后是一个面具（170 毫秒）和形状。情绪认知 ANOVA 的诊断不显着。在枕部区域存在显着的诊断意识相互作用。BD 和 SMD 显示非意识与意识活动增加；HV 显示出相反的模式。当受试者看到愤怒或中性的面孔时，面部情绪处理区域存在情绪诊断相互作用，包括 L 中央前回、R 后扣带回、R 颞上回、R 枕中回和 L 内侧额叶回。不管意识如何，