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Developmental effects of decision-making on sensitivity to reward: an fMRI study.
Developmental Cognitive Neuroscience ( IF 4.6 ) Pub Date : 2012-05-03 , DOI: 10.1016/j.dcn.2012.04.002
Johanna M Jarcho 1 , Brenda E Benson , Rista C Plate , Amanda E Guyer , Allison M Detloff , Daniel S Pine , Ellen Leibenluft , Monique Ernst
Affiliation  

Studies comparing neural correlates of reward processing across development yield inconsistent findings. This challenges theories characterizing adolescents as globally hypo- or hypersensitive to rewards. Developmental differences in reward sensitivity may fluctuate based on reward magnitude, and on whether rewards require decision-making. We examined whether these factors modulate developmental differences in neural response during reward anticipation and/or receipt in 26 adolescents (14.05 ± 2.37 yrs) and 26 adults (31.25 ± 8.23 yrs). Brain activity was assessed with fMRI during reward anticipation, when subjects made responses with–vs.–without decision-making, to obtain large–vs.–small rewards, and during reward receipt. When reward-receipt required decision-making, neural activity did not differ by age. However, when reward receipt did not require decision-making, neural activity varied by development, reward magnitude, and stage of the reward task. During anticipation, adolescents, but not adults, exhibited greater activity in the insula, extending into putamen, and cingulate gyrus for large–vs.–small incentives. During feedback, adults, but not adolescents, exhibited greater activity in the precuneus for large–vs.–small incentives. These data indicate that age-related differences in reward sensitivity cannot be characterized by global hypo- or hyper-responsivity. Instead, neural responding in striatum, prefrontal cortex and precuneus is influenced by both situational demands and developmental factors. This suggests nuanced maturational effects in adolescent reward sensitivity.



中文翻译:

决策对奖励敏感性的发展影响:fMRI 研究。

比较整个发育过程中奖励处理的神经相关性的研究产生了不一致的发现。这挑战了将青少年描述为全球对奖励低敏感或过度敏感的理论。奖励敏感性的发展差异可能会根据奖励幅度以及奖励是否需要决策而波动。我们检查了这些因素是否在 26 名青少年(14.05 ± 2.37 岁)和 26 名成人(31.25 ± 8.23 岁)的奖励预期和/或接受期间调节神经反应的发育差异。在奖励预期期间,当受试者在做出与没有决策的情况下做出反应,以获得大与小奖励时,以及在奖励接收期间,使用 fMRI 评估大脑活动。当奖励接收需要决策时,神经活动不会因年龄而异。然而,当奖励接收不需要决策时,神经活动因发育、奖励大小和奖励任务的阶段而异。在预期期间,青少年而不是成年人在脑岛中表现出更大的活动,延伸到壳核和扣带回,以获得大对小激励。在反馈过程中,成年人,而不是青少年,在大与小激励下的楔前叶表现出更大的活动。这些数据表明,与年龄相关的奖励敏感性差异不能以整体低反应或高反应为特征。相反,纹状体、前额叶皮层和楔前叶的神经反应受情境需求和发育因素的影响。这表明对青少年奖励敏感性的细微成熟影响。和奖励任务的阶段。在预期期间,青少年而不是成年人在脑岛中表现出更大的活动,延伸到壳核和扣带回,以获得大对小激励。在反馈过程中,成年人,而不是青少年,在大与小激励下的楔前叶表现出更大的活动。这些数据表明,与年龄相关的奖励敏感性差异不能以整体低反应或高反应为特征。相反,纹状体、前额叶皮层和楔前叶的神经反应受情境需求和发育因素的影响。这表明对青少年奖励敏感性的细微成熟影响。和奖励任务的阶段。在预期期间,青少年而不是成年人在脑岛中表现出更大的活动,延伸到壳核和扣带回,以获得大对小激励。在反馈过程中,成年人,而不是青少年,在大与小激励下的楔前叶表现出更大的活动。这些数据表明,与年龄相关的奖励敏感性差异不能以整体低反应或高反应为特征。相反,纹状体、前额叶皮层和楔前叶的神经反应受情境需求和发育因素的影响。这表明对青少年奖励敏感性的细微成熟影响。——小激励。在反馈过程中,成年人,而不是青少年,在大与小激励下的楔前叶表现出更大的活动。这些数据表明,与年龄相关的奖励敏感性差异不能以整体低反应或高反应为特征。相反,纹状体、前额叶皮层和楔前叶的神经反应受情境需求和发育因素的影响。这表明对青少年奖励敏感性的细微成熟影响。——小激励。在反馈过程中,成年人,而不是青少年,在大与小激励下的楔前叶表现出更大的活动。这些数据表明,与年龄相关的奖励敏感性差异不能以整体低反应或高反应为特征。相反,纹状体、前额叶皮层和楔前叶的神经反应受情境需求和发育因素的影响。这表明对青少年奖励敏感性的细微成熟影响。前额叶皮层和楔前叶受情境需求和发育因素的影响。这表明对青少年奖励敏感性的细微成熟影响。前额叶皮层和楔前叶受情境需求和发育因素的影响。这表明对青少年奖励敏感性的细微成熟影响。

更新日期:2012-05-03
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