Alterations in hormone concentrations, including adrenocorticotropin, corticotropin releasing hormone, and cortisol have been reported in patients with obsessive compulsive disorder (OCD). Dehydroepiandrosterone (DHEA) and its sulfated metabolite, DHEA-S, have not been assessed in patients with OCD. We report 24-h serum DHEA, DHEA-S, and cortisol concentrations in a young man with OCD and 15 healthy young men. Circadian patterns of DHEA and cortisol were markedly different in the subject with OCD than in the control subjects. DHEA and DHEA-S concentrations were substantially higher in the OCD subject than in the control subjects. In contrast, cortisol concentrations were similar in the OCD subject and the control subjects. Future clinical studies are needed to evaluate the significance of DHEA and DHEA-S in OCD.

中文翻译：

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强迫症中神经类固醇的失调。

据报道，强迫症 (OCD) 患者的激素浓度发生变化，包括促肾上腺皮质激素、促肾上腺皮质激素释放激素和皮质醇。尚未在强迫症患者中评估脱氢表雄酮 (DHEA) 及其硫酸化代谢物 DHEA-S。我们报告了一名患有强迫症的年轻男性和 15 名健康年轻男性的 24 小时血清 DHEA、DHEA-S 和皮质醇浓度。患有强迫症的受试者的 DHEA 和皮质醇的昼夜节律模式与对照受试者明显不同。OCD 受试者的 DHEA 和 DHEA-S 浓度明显高于对照组。相比之下，强迫症受试者和对照受试者的皮质醇浓度相似。需要未来的临床研究来评估 DHEA 和 DHEA-S 在 OCD 中的重要性。