The single-dose disposition kinetics of cefonicid were determined in clinically normal lactating goats (n = 6) after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration of a conventional formulation, and after subcutaneous administration of a long-acting formulation (SC-LA). Cefonicid concentrations were determined by high performance liquid chromatography with ultraviolet detection. The concentration-time data were analysed by noncompartmental pharmacokinetic methods. Steady-state volume of distribution (Vss ) and clearance (Cl) of cefonicid after IV administration were 0.14 ± 0.03 L/kg and 0.51 ± 0.07 L/h·kg, respectively. Following IM, SC and SC-LA administration, cefonicid achieved maximum plasma concentrations of 14.46 ± 0.82, 11.98 ± 1.92 and 17.17 ± 2.45 mg/L at 0.26 ± 0.13, 0.42 ± 0.13 and 0.83 ± 0.20 hr, respectively. The absolute bioavailabilities after IM, SC and SC-LA routes were 75.34 ± 11.28%, 71.03 ± 19.14% and 102.84 ± 15.155%, respectively. After cefonicid analysis from milk samples, no concentrations were found above LOQ at any sampling time. From these data, cefonicid administered at 20 mg/kg each 12 hr after SC-LA could be effective to treat bacterial infections in lactating animals not affected by mastitis problems.

中文翻译：

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静脉，肌肉内和皮下给药后，以及用于皮下给药的长效制剂给药后，头孢尼类在哺乳山羊中的药代动力学。

在常规配方的静脉内（IV），肌肉内（IM）和皮下（SC）给药以及长效皮下给药后，在临床上正常泌乳的山羊（n = 6）中测定了头孢尼酮的单剂量动力学配方（SC-LA）。通过高效液相色谱法和紫外线检测法测定头孢烯酮的浓度。通过非房室药代动力学方法分析浓度时间数据。静脉注射后头孢类的稳态分布体积（Vss）和清除率（Cl）分别为0.14±0.03 L / h和0.51±0.07 L / h·kg。IM，SC和SC-LA给药后，头孢尼西酯在0.26±0.13、0.42±0.13和0.83±0.20 hr时分别达到最大血浆浓度14.46±0.82、11.98±1.92和17.17±2.45 mg / L。IM，SC和SC-LA路线后的绝对生物利用度分别为75.34±11.28％，71.03±19.14％和102.84±15.155％。对牛奶样品中的头孢烯类进行分析后，在任何采样时间均未发现高于最低定量限的浓度。根据这些数据，在SC-LA后每12小时以20 mg / kg的剂量注射头孢尼酮可能有效治疗不受乳腺炎问题影响的泌乳动物的细菌感染。