当前位置: X-MOL 学术WIREs Nanomed. Nanobiotechnol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Protein-protected metal nanoclusters: An emerging ultra-small nanozyme.
WIREs Nanomedicine and Nanobiotechnology ( IF 6.9 ) Pub Date : 2019-11-14 , DOI: 10.1002/wnan.1602
Xiangqin Meng 1, 2 , Iman Zare 3 , Xiyun Yan 1, 2, 4 , Kelong Fan 2
Affiliation  

Protein-protected metal nanoclusters (MNCs), typically consisting of several to a hundred metal atoms with a protein outer layer used for protecting clusters from aggregation, are excellent fluorescent labels for biomedical applications due to their extraordinary photoluminescence, facile synthesis and good biocompatibility. Interestingly, many protein-protected MNCs have also been reported to exhibit intrinsic enzyme-like activities, namely peroxidase, oxidase and catalase activities, and are consequently used for biological analysis and environmental treatment. These findings have extended the horizon of protein-protected MNCs' properties as well as their application in various fields. Furthermore, in the field of nanozymes, protein-protected MNCs have emerged as an outstanding new addition. Due to their ultra-small size (<2 nm), they usually have higher catalytic activity, more suitable size for in vivo application, better biocompatibility and photoluminescence in comparison with large size nanozymes. In this review, we will systematically introduce the significant advances in this field and critically discuss the challenges that lie ahead. Ultra-small nanozymes based on protein-protected MNCs are on the verge of attracting great interest across various disciplines and will stimulate research in the fields of nanotechnology and biology. This article is characterized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology-Inspired Nanomaterials > Protein and Virus-Based Structures.

中文翻译:

蛋白质保护的金属纳米簇:一种新兴的超小型纳米酶。

蛋白质保护的金属纳米簇(MNC)通常由几至一百个金属原子组成,其蛋白质外层用于保护簇免于聚集,由于其非凡的光致发光,合成简便和良好的生物相容性,因此是生物医学应用的出色荧光标记。有趣的是,据报道,许多蛋白质保护的MNC都表现出固有的类似酶的活性,即过氧化物酶,氧化酶和过氧化氢酶活性,因此被用于生物学分析和环境处理。这些发现扩展了蛋白质保护的跨国公司的性质及其在各个领域中的应用范围。此外,在纳米酶领域,蛋白质保护的跨国公司已作为杰出的新成员出现。由于尺寸极小(<2 nm),与大尺寸纳米酶相比,它们通常具有更高的催化活性,更适合体内应用的尺寸,更好的生物相容性和光致发光。在这篇综述中,我们将系统地介绍该领域的重大进展,并批判性地讨论未来的挑战。基于受蛋白质保护的MNC的超小型纳米酶正处于各个学科领域的巨大兴趣,并将激发纳米技术和生物学领域的研究。本文的特点是:治疗方法和药物发现>新兴技术生物学启发的纳米材料>基于蛋白质和病毒的结构。与大尺寸纳米酶相比,具有更好的生物相容性和光致发光性。在这篇评论中,我们将系统地介绍该领域的重大进展,并批判性地讨论未来的挑战。基于受蛋白质保护的MNC的超小型纳米酶正处于各个学科领域的巨大兴趣,并将激发纳米技术和生物学领域的研究。本文的特点是:治疗方法和药物发现>新兴技术生物学启发的纳米材料>基于蛋白质和病毒的结构。与大尺寸纳米酶相比,具有更好的生物相容性和光致发光性。在这篇综述中,我们将系统地介绍该领域的重大进展,并批判性地讨论未来的挑战。基于受蛋白质保护的MNC的超小型纳米酶正处于各个学科领域的巨大兴趣,并将激发纳米技术和生物学领域的研究。本文的特点是:治疗方法和药物发现>新兴技术生物学启发的纳米材料>基于蛋白质和病毒的结构。基于受蛋白质保护的MNC的超小型纳米酶正处于各个学科领域的巨大兴趣,并将激发纳米技术和生物学领域的研究。本文的特点是:治疗方法和药物发现>新兴技术生物学启发的纳米材料>基于蛋白质和病毒的结构。基于受蛋白质保护的MNC的超小型纳米酶正处于各个学科领域的巨大兴趣,并将激发纳米技术和生物学领域的研究。本文的特点是:治疗方法和药物发现>新兴技术生物学启发的纳米材料>基于蛋白质和病毒的结构。
更新日期:2019-11-01
down
wechat
bug