PURPOSE To evaluate the three-dimensional choroidal vascularity index (CVI) in the eyes with treatment-naïve acute central serous chorioretinopathy (CSC) using swept-source optical coherence tomography (SS OCT). METHODS In this prospective cross-sectional study, OCT and OCT angiography covered an area of 12 × 12 mm centered on the fovea. Three-dimensional CVI was defined as the ratio of the choroidal vascular luminal volume to the total choroidal volume. The location of pigment epithelial detachment (PED) and the area with abnormal perfusion at choriocapillary layer were compared with the distribution of the three-dimensional CVI. RESULTS Thirty-two eyes with treatment-naïve acute CSC, 18 fellow eyes, and 48 control eyes were enrolled. Three-dimensional CVI had good repeatability on control eyes, with a coefficient of variation of 0.166. The mean CVI in the scan area was 0.35 in the eyes with CSC, 0.34 in the fellow eyes of CSC, and 0.30 in the control eyes. The overall CVI in the control eyes was significantly lower than that in the eyes with CSC and that in fellow eyes (P < 0.001 and P = 0.006, respectively). The eyes with CSC and the fellow eyes had significantly higher CVI values at the posterior pole and the drainage routes of choroidal veins. In the eyes with CSC, PEDs and choriocapillary with abnormal perfusion colocalized with the dilated choroidal vessels, which had high three-dimensional CVI values. CONCLUSION Increased three-dimensional CVI suggested an increased vascular component in the eyes with CSC and in fellow eyes. The three-dimensional CVI is a useful imaging marker of choroidal diseases that volumetrically assesses the choroidal vasculature and might advance our understanding of CSC pathophysiology.

中文翻译：

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扫描源光学相干断层扫描在急性中心性浆液性脉络膜视网膜病变中的三维脉络膜血管指数。

目的使用扫频源光学相干断层扫描（SS OCT）评估未接受过治疗的急性中枢性浆液性脉络膜视网膜病变（CSC）的眼睛中的三维脉络膜血管指数（CVI）。方法在这项前瞻性横断面研究中，OCT和OCT血管造影术覆盖了以中央凹为中心的12×12 mm区域。三维CVI定义为脉络膜血管腔体积与脉络膜总体积之比。将色素上皮脱离（PED）的位置和脉络膜毛细血管层灌注异常的区域与三维CVI的分布进行了比较。结果招募了32只未接受过治疗的急性CSC眼，18只同伴眼和48只对照眼。三维CVI在对照眼上具有良好的重复性，变异系数为0.166。扫描区域的平均CVI在CSC眼中为0.35，在CSC的另一只眼中为0.34，在对照眼中为0.30。对照眼的总体CVI显着低于CSC眼和其他眼睛（分别为P <0.001和P = 0.006）。CSC眼和另一只眼的后极和脉络膜静脉引流路线的CVI值明显较高。在CSC的眼中，PED和脉络膜毛细血管灌注异常与扩张的脉络膜血管共定位，这些血管的三维CVI值较高。结论三维CVI增加提示CSC眼睛和另一只眼睛的血管成分增加。