Some previous studies already explored associations between interleukin-10 (IL-10) polymorphisms and ischemic stroke (IS), with conflicting results. In this meta-analysis, we aimed to better analyze the relationship between IL-10 polymorphisms and IS in a larger pooled population. We performed a systematic search of PubMed, Web of Science, Embase and CNKI. We calculated pooled odds ratios (ORs) and 95% confidence intervals (CIs) to estimate associations between IL-10 polymorphisms and IS. Totally 17 studies with 3610 cases and 5,171 controls were included. A significant association with IS was observed for IL-10 rs1800896 polymorphism in AA versus GG + GA (recessive model, p = .001, OR = 1.42, 95%CI 1.15-1.75, I2 = 48%) in overall population. Further subgroup analyses showed that rs1800896 polymorphism was significantly associated with cerebral infarction in GG versus GA + AA (dominant model, p = .02, OR = 2.04, 95%CI 1.14-3.64, I2 = 59%), GA versus GG + AA (overdominant model, p = .03, OR = 0.50, 95%CI 0.27-0.93, I2 = 64%) and G versus A (allele model, p = .01, OR = 1.92, 95%CI 1.16-3.17, I2 = 53%). Nevertheless, no any positive findings were detected for rs1800871 and rs1800872 polymorphisms in pooled analyses. In conclusion, our findings indicated that IL-10 rs1800896 polymorphism was significantly associated with individual susceptibility to IS, especially for cerebral infarction.

中文翻译：

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白细胞介素10多态性与缺血性中风易感性之间的关系：荟萃分析。

先前的一些研究已经探索了白介素10（IL-10）多态性与缺血性卒中（IS）之间的关联，但结果却相互矛盾。在这项荟萃分析中，我们旨在更好地分析较大人群中IL-10多态性与IS之间的关系。我们对PubMed，Web of Science，Embase和CNKI进行了系统搜索。我们计算了合并的优势比（OR）和95％置信区间（CI），以估计IL-10多态性与IS之间的关联。总共包括3610例病例和5171例对照的17项研究。在总体人群中，AA与GG + GA（隐性模型，p = .001，OR = 1.42，95％CI 1.15-1.75，I2 = 48％）中的IL-10 rs1800896多态性与IS显着相关。进一步的亚组分析显示rs1800896多态性与GG与GA + AA的脑梗死显着相关（主要模型，p = .02，OR = 2.04，95％CI 1.14-3.64，I2 = 59％），GA与GG + AA （主要模型，p = .03，OR = 0.50，95％CI 0.27-0.93，I2 = 64％），G与A（等位基因模型，p = .01，OR = 1.92，95％CI 1.16-3.17，I2 = 53％）。但是，在汇总分析中未检测到rs1800871和rs1800872多态性的任何阳性发现。总之，我们的发现表明IL-10 rs1800896多态性与个体对IS的易感性显着相关，尤其是对于脑梗塞。I2 = 64％），G与A（等位基因模型，p = 0.01，OR = 1.92，95％CI 1.16-3.17，I2 = 53％）。但是，在汇总分析中未检测到rs1800871和rs1800872多态性的任何阳性发现。总之，我们的发现表明IL-10 rs1800896多态性与个体对IS的易感性显着相关，尤其是对于脑梗塞。I2 = 64％），G与A（等位基因模型，p = 0.01，OR = 1.92，95％CI 1.16-3.17，I2 = 53％）。但是，在汇总分析中未检测到rs1800871和rs1800872多态性的任何阳性发现。总之，我们的发现表明IL-10 rs1800896多态性与个体对IS的易感性显着相关，尤其是对于脑梗塞。