Exploring the Prevalence of Clozapine Phenotypic Poor Metabolizers in 4 Asian Samples: They Ranged Between 2% and 13.,Journal of Clinical Psychopharmacology

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Exploring the Prevalence of Clozapine Phenotypic Poor Metabolizers in 4 Asian Samples: They Ranged Between 2% and 13.
Journal of Clinical Psychopharmacology ( IF 2.9 ) Pub Date : 2019-11-7 , DOI: 10.1097/jcp.0000000000001125
Can-Jun Ruan ₁ , Chuan-Yue Wang ₂ , Yi-Lang Tang ₃ , Shih-Ku Lin ₄ , Seung-Tae Lee ₅ , Kyung Sue Hong ₆ , Anto P Rajkumar _{7,

8} , Kuruthukulangara S Jacob ₇ , Jose de Leon ₉

Affiliation

From the Laboratory of Clinical Psychopharmacology, The National Clinical Research Centre for Mental Disorders, Beijing Key Laboratory of Mental Disorders.
Department of Psychiatry, The National Clinical Research Centre for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta.
Department of General Psychiatry, Taipei City, Psychiatric Center.
Department of Laboratory Medicine, Yonsei University College of Medicine.
Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
Department of Psychiatry, Christian Medical College, Vellore, India.
Department of Old Age Psychiatry, Institute of Psychiatry, Psychology, & Neuroscience, King's College London, London.
Mental Health Research Center, Eastern State Hospital, Lexington, KY and Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada.

Clozapine clearance is influenced by sex, smoking status, ethnicity, coprescription of inducers or inhibitors, obesity, and inflammation. In 126 Beijing inpatients, we measured repeated trough steady-state serum concentrations and identified 4% (5/126) who were phenotypical poor metabolizers (PMs); none were ultrarapid metabolizers (UMs). They were defined as being 2 SDs beyond the means of total clozapine concentration/dose ratios stratified by sex and smoking. Using this definition, this study explores the prevalence of PMs and UMs using data from 4 already published Asian samples. Three samples were East Asian (Beijing 2, Taipei, and Seoul); one was from South India (Vellore).

更新日期：2020-12-17

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