The negative symptoms of schizophrenia pose a heavy burden on patients and relatives and represent an unmet therapeutic need. The observed association of negative symptoms with impaired reward system function has stimulated research on prodopaminergic agents as potential adjunctive treatments.

中文翻译：

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治疗精神分裂症阴性症状的前多巴胺能药物：随机对照试验的系统评价和荟萃分析。

精神分裂症的阴性症状给患者和亲属带来沉重负担，并且代表了未满足的治疗需求。观察到的消极症状与奖赏系统功能受损之间的联系，刺激了对作为可能的辅助治疗药物的原多巴胺能药物的研究。