One of the major topics in magnetobiology is the biological effects of strong static magnetic field (SMF) on living organisms. However, there has been a paucity of the comprehensive study of the long-term effects of strong SMF on an animal's development. Here, we explored this question with zebrafish, an excellent model organism for developmental study. In our research, zebrafish eggs, just after fertilization, were exposed to a 9.0 T SMF for 24 h, the critical period of post-fertilization development from cleavage to segmentation. The effects of strong SMF exposure on the following developmental progress of zebrafish were studied until 6 days post-fertilization (dpf). Results showed that 9.0 T SMF exposure did not influence the survival or the general developmental scenario of zebrafish embryos. However, it slowed down the developmental pace of the whole animal, and the late developers would catch up with their control peers after the SMF was removed. We proposed a mechanical model and deduced that the development delaying effect was caused by the interference of SMF in microtubule and spindle positioning during mitosis, especially in early cleavages. Our research data provide insights into how strong SMF influences the developing organisms through basic physical interactions with intracellular macromolecules.

中文翻译：

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强的静磁场延迟了斑马鱼的早期发育。

磁生物学的主要主题之一是强静电磁场（SMF）对生物的生物学影响。但是，关于强SMF对动物发育的长期影响的综合研究很少。在这里，我们用斑马鱼探索了这个问题，斑马鱼是用于发育研究的优秀模型生物。在我们的研究中，将刚受精后的斑马鱼卵暴露于9.0 T SMF中24小时，这是受精后从分裂到分裂的关键时期。研究了强SMF暴露对斑马鱼随后发育进程的影响，直到受精后6天（dpf）。结果表明，暴露于9.0 T SMF不会影响斑马鱼胚胎的存活或总体发育情况。然而，它减慢了整个动物的发育速度，并且在删除SMF之后，已故的开发人员将赶上他们的控制同行。我们提出了一个力学模型，并推论出发育延迟的影响是由有丝分裂对有丝分裂期间微管和纺锤体定位的干扰引起的，特别是在早期卵裂中。我们的研究数据提供了有关强SMF通过与细胞内大分子的基本物理相互作用如何影响发育中的生物的见解。