Childhood maltreatment and polygenic risk in bipolar disorders.,Bipolar Disorders

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Childhood maltreatment and polygenic risk in bipolar disorders.
Bipolar Disorders ( IF 5.0 ) Pub Date : 2019-11-13 , DOI: 10.1111/bdi.12851
Monica Aas _{1,

2} , Frank Bellivier _{3,

4,

5,

6} , Francesco Bettella ₁ , Chantal Henry _{7,

8,

9,

10} , Sebastien Gard _{6,

11} , Jean-Pierre Kahn _{6,

12} , Trine V Lagerberg ₂ , Sofie R Aminoff _{1,

2} , Ingrid Melle _{1,

2} , Marion Leboyer _{6,

7,

8,

13} , Stéphane Jamain ₁₃ , Ole A Andreassen _{1,

2,

10} , Bruno Etain _{3,

4,

5,

6,

10}

Affiliation

NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Université Paris Diderot, Paris, France.
INSERM U1144, Faculté de Pharmacie de Paris, Université Paris Descartes, Université Paris Diderot, Université Sorbonne Paris Cité, Paris, France.
AP-HP, GH Saint-Louis - Lariboisière - F. Widal, Département de Psychiatrie et de Médecine Addictologique, Paris, France.
Fondation Fondamental, Créteil, France.
AP-HP, Pôle de Psychiatry, DHU Pepsy, Hôpitaux Universitaires Henri Monody, Créteil, France.
Université Paris-Est-Creteil-Val de Marne, Créteil, France.
Institut Pasteur, Unité Perception et Mémoire, Centre National de la Recherche Scientifique, Paris, France.
ENBREC, European Network of Bipolar Research Expert Centres (ENBREC), Paris, France.
Centre Expert Trouble Bipolaire, Service de psychiatrie adulte, Hôpital Charles Perrens, Bordeaux, France.
Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, Nancy, France.
Inserm, U955, Equipe Psychiatrie Translationnelle, Créteil, France.

Childhood maltreatment is a well‐known risk factor for developing a more severe and complex form of bipolar disorders (BD). However, knowledge is scarce about the interactions between childhood maltreatment and underlying genetic vulnerability on the clinical expression of BD.

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