The innate and adaptive arms of the immune system tightly regulate immune responses in order to maintain homeostasis and host defense. The interaction between those two systems is critical in the activation and suppression of immune responses which if unchecked may lead to chronic inflammation and autoimmunity. γδ T cells are non-conventional lymphocytes, which express T cell receptor (TCR) γδ chains on their surface and straddle between innate and adaptive immunity. Recent advances in of γδ T cell biology have allowed us to expand our understanding of γδ T cell in the dysregulation of immune responses and the development of autoimmune diseases. In this review, we summarize current knowledge on γδ T cells and their roles in skin and joint inflammation as commonly observed in rheumatic diseases.

中文翻译：

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风湿性疾病中的 γδ T 细胞：从基本机制到自身免疫。

免疫系统的先天和适应性武器严格调节免疫反应，以维持体内平衡和宿主防御。这两个系统之间的相互作用对于免疫反应的激活和抑制至关重要，如果不加以控制，可能会导致慢性炎症和自身免疫。γδ T 细胞是非常规淋巴细胞，其表面表达 T 细胞受体 (TCR) γδ 链，介于先天免疫和适应性免疫之间。γδ T 细胞生物学的最新进展使我们能够扩大对 γδ T 细胞在免疫反应失调和自身免疫性疾病发展中的理解。在这篇综述中，我们总结了当前关于 γδ T 细胞的知识及其在风湿性疾病中常见的皮肤和关节炎症中的作用。