Low-grade inflammation is recognized as an important factor in the development and progression of a multitude of diseases including type 2 diabetes mellitus and cardiovascular disease. The potential of using antibody-based therapies that neutralize key players of low-grade inflammation has gained scientific momentum as a novel therapeutic strategy in metabolic diseases. As interleukin-6 (IL-6) is traditionally considered a key pro-inflammatory factor, the potential of expanding the use of anti-IL-6 therapies to metabolic diseases is intriguing. However, IL-6 is a molecule of a very pleiotropic nature that regulates many aspects of not only inflammation but also metabolism. In this review, we give a brief overview of the pro- and anti-inflammatory aspects of IL-6 and provide an update on its role in metabolic regulation, with a specific focus on glucose homeostasis and adipose tissue metabolism. Finally, we shall discuss the metabolic implications and clinical potential of blocking IL-6 signaling, focusing on glucose homeostasis and lipid metabolism.

中文翻译：

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IL-6在葡萄糖稳态和脂质代谢中的作用。

低度炎症被认为是包括2型糖尿病和心血管疾病在内的多种疾病的发生和发展的重要因素。使用基于抗体的疗法中和低度炎症关键参与者的潜力已获得科学动力，成为代谢疾病的一种新型治疗策略。传统上将白介素6（IL-6）视为关键的促炎因子，因此将抗IL-6疗法的应用范围扩大到代谢疾病的潜力令人着迷。但是，IL-6是一种非常多效的分子，不仅调节炎症而且还调节新陈代谢的许多方面。在这篇评论中，我们简要概述了IL-6的促炎和抗炎方面，并提供了其在代谢调节中的作用的最新进展，特别关注葡萄糖稳态和脂肪组织代谢。最后，我们将讨论阻断IL-6信号传导的代谢影响和临床潜力，重点是葡萄糖稳态和脂质代谢。