The klotho protein is secreted primarily by the kidneys. It is responsible for phosphate homeostasis and has an anti-aging, anti-inflammatory, and anti-oxidative stress role. Obstructive sleep apnea (OSA) is associated with an enhanced systemic inflammation and oxidative stress, but mechanisms that regulate these processes are poorly understood. The aim of the study was to investigate the plasma levels of klotho in OSA. Twenty-one previously untreated patients with OSA (56 ± 13 years, 12 males) and 41 non-OSA control volunteers (48 ± 16 years, 8 males) participated in the study. Medical history has been taken; participants filled out the Epworth Sleepiness Scale. C-reactive protein and renal function, glucose and lipid profile measurements were performed in sera; klotho was determined in citrate-treated plasma samples. Levels of plasma klotho were decreased in OSA (519.1 ± 164.9 pg/mL) versus controls (700.8 ± 431.4 pg/mL, p = 0.02). Reduced klotho concentrations were associated with markers of overnight hypoxemia determined with O₂ desaturation index (r = −0.31, p = 0.01), percentage of sleep time spent with saturation <90% (r = −0.41, p < 0.01), and minimal saturation during sleep (r = 0.33, p = 0.01). Interestingly, there was no relationship with apnea-hypopnea index, total sleep time, or arousal index (all p > 0.05). Significant association was also found between low plasma klotho levels and the presence of hypertension (p < 0.05). Our results suggest that chronic intermittent hypoxia reduces the levels of klotho in OSA, which may contribute to the development of hypertension. Decreased klotho levels may play a role in enhanced systemic inflammation in OSA and may be a future target for drug development.

中文翻译：

---

阻塞性睡眠呼吸暂停中抗衰老Klotho的水平降低。

klotho蛋白主要由肾脏分泌。它负责磷酸盐的稳态，并具有抗衰老，抗炎和抗氧化的作用。阻塞性睡眠呼吸暂停（OSA）与全身性炎症和氧化应激加剧有关，但调节这些过程的机制了解甚少。该研究的目的是研究OSA中血浆klotho的水平。二十一个先前未接受过治疗的OSA患者（56±13岁，男性12位）和41位非OSA对照志愿者（48±16岁，男性8位）参加了该研究。有病史；参与者填写了Epworth嗜睡量表。在血清中进行C反应蛋白和肾功能，葡萄糖和脂质分布的测量。在柠檬酸盐处理的血浆样品中测定了klotho。p  = 0.02）。降低的klotho浓度与由O ₂去饱和指数（r  = -0.31，p  = 0.01），饱和度<90％（r  = -0.41，p  <0.01）所花费的睡眠时间百分比确定的过夜低氧血症的标志物有关睡眠期间饱和度（r  = 0.33，p  = 0.01）。有趣的是，与呼吸暂停低通气指数，总睡眠时间或唤醒指数没有关系（所有p  > 0.05）。还发现血浆血浆Klotho水平低与高血压的存在之间存在显着关联（p <0.05）。我们的结果表明，慢性间歇性缺氧会降低OSA中的克洛索水平，这可能有助于高血压的发展。降低的klotho水平可能在OSA的全身性炎症增强中起作用，并且可能成为药物开发的未来目标。