Purpose: Nonconventional vapor products (NVP), designed to reduce exposure to cigarette smoke toxicants (CSTs), could cause changes in biomarkers of potential harm (BoPH). Although, NVPs reduced CSTs exposure compared to conventional cigarettes (CC), the changes in the BoPH values varied among the studies. Hence, further information on BoPH using NVPs is needed. Material and methods: The data of two similarly designed studies using a kind of NVP, a noncombustion and nonheating inhaler type of smokeless tobacco product (NCIT) used under 31-day confinement, were pooled, and the differences in 15 BoPH between smokers and nonsmokers at baseline and between the 1 mg tar CC (CC1) group and NCIT group at Day 28/29 were analyzed. Results: At baseline, the levels of eight BoPH (red blood cells, white blood cells, 8-epi-prostaglandin F2α, 8-hydroxy-2'-deoxyguanosine, malondialdehyde, 11-dehydrothromboxane B2, total cholesterol and glucose) were significantly different between smokers and nonsmokers. At Day 28/29, the levels of six BoPH were significantly different between NCIT and CC1 (8-epi-prostaglandin F2α, malondialdehyde, 11-dehydrothromboxane B2: CC1 > NCIT, total bilirubin, low-density lipoprotein cholesterol and total cholesterol: CC1 < NCIT). Conclusions: Reduced exposure to CSTs has favorable effects on BoPH associated with oxidative stress, antioxidant capacity and platelet activation/coagulation but not in lipid metabolism.

中文翻译：

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减少吸烟对成年吸烟者潜在危害生物标志物变化的影响：两项临床研究的综合分析结果。


目的：非常规蒸气产品 (NVP) 旨在减少接触香烟烟雾毒物 (CST)，可能会导致潜在危害的生物标志物 (BoPH) 发生变化。尽管与传统香烟 (CC) 相比，NVP 减少了 CST 暴露，但各研究中 BoPH 值的变化各不相同。因此，需要有关使用 NVP 的 BoPH 的更多信息。材料和方法：将两项设计相似的研究数据进行汇总，使用一种 NVP（一种在 31 天禁闭状态下使用的非燃烧非加热吸入器型无烟烟草产品 (NCIT)），并比较吸烟者和非吸烟者之间 15 BoPH 的差异分析了基线以及第 28/29 天 1 mg 焦油 CC (CC1) 组和 NCIT 组之间的情况。结果：基线时，八种 BoPH（红细胞、白细胞、8-表前列腺素 F2α、8-羟基-2'-脱氧鸟苷、丙二醛、11-脱氢血栓素 B2、总胆固醇和葡萄糖）水平显着不同吸烟者和不吸烟者之间。第28/29天，NCIT和CC1之间的六项BoPH水平存在显着差异（8-表前列腺素F2α、丙二醛、11-脱氢血栓烷B2：CC1 > NCIT、总胆红素、低密度脂蛋白胆固醇和总胆固醇：CC1 <NCIT）。结论：减少 CST 暴露对与氧化应激、抗氧化能力和血小板活化/凝血相关的 BoPH 具有有利影响，但对脂质代谢没有影响。