Fundamental cellular processes such as division, polarization, and motility require the tightly regulated spatial and temporal assembly and disassembly of the underlying actin cytoskeleton. The actin cytoskeleton has been long viewed as a central player facilitating diverse mechanotransduction pathways due to the notion that it is capable of receiving, processing, transmitting, and generating mechanical stresses. Recent work has begun to uncover the roles of mechanical stresses in modulating the activity of key regulatory actin-binding proteins and their interactions with actin filaments, thereby controlling the assembly (formin and Arp2/3 complex) and disassembly (ADF/Cofilin) of actin filament networks. In this review, we will focus on discussing the current molecular understanding of how members of the formin protein family sense and respond to forces and the potential implications for formin-mediated mechanotransduction in cells.

中文翻译：

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感受力量：formin在机械转导中的作用。

基本的细胞过程（例如分裂，极化和运动）需要严格控制潜在肌动蛋白细胞骨架的时空组装和拆​​卸。由于肌动蛋白的细胞骨架能够接收，处理，传递和产生机械应力，因此肌动蛋白的细胞骨架长期以来一直被认为是促进多种机械转导途径的重要角色。最近的工作已开始揭示机械应力在调节关键调节肌动蛋白结合蛋白的活性及其与肌动蛋白丝之间的相互作用中的作用，从而控制肌动蛋白的组装（福尔马林和Arp2 / 3复合物）和拆卸（ADF / Cofilin）灯丝网络。在这篇评论中