Cells are the building units of living organisms and consequently adapt to their environment by modulating their intracellular architecture, in particular the position of their nucleus. Important efforts have been made to decipher the molecular mechanisms involved in nuclear positioning. The LINC complex at the nuclear envelope is a very important part of the molecular connectivity between the cell outside and the intranuclear compartment, and thus emerged as a central player in nuclear mechanotransduction. More recent concepts in nuclear mechanotransduction came from studies involving nuclear confined migration, compression or swelling. Also, the effect of nuclear mechanosensitive properties in driving cell differentiation raises the question of nuclear mechanotransduction and gene expression and recent efforts have been done to tackle it, even though it remains difficult to address in a direct manner. Eventually, an original mechanism of nucleus positioning, mechanotransduction and regulation of gene expression in the non-adherent, non-polarized mouse oocyte, highlights the fact that nuclear positioning is an important developmental issue.

中文翻译：

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核定位是细胞命运的整合者。

细胞是生命有机体的构建单元，因此通过调节其细胞内结构，特别是其细胞核的位置来适应其环境。为了破译涉及核定位的分子机制，已经做出了重要的努力。核被膜上的LINC复合物是细胞外部与核内区室之间分子连接的非常重要的部分，因此成为核机械转导的核心参与者。核机械转导的最新概念来自涉及核限制迁移，压缩或膨胀的研究。同样，核机械敏感性特性在驱动细胞分化中的作用提出了核机械转导和基因表达的问题，并且最近为解决该问题进行了努力，即使仍然难以直接解决。最终，非粘着，非极化小鼠卵母细胞中核定位，机械转导和基因表达调节的原始机制突显了核定位是一个重要的发展问题的事实。