Although clotrimazole was first used against fungal infections, a body of research was later developed indicating that this drug has anticancer properties as well. The mechanism of action is based on the inhibition of mitochondrial-bound glycolytic enzymes and calmodulin, which starves cancer cells of energy. Clotrimazole and its derivatives have been shown to decrease rates of cancer cell proliferation, induce G1 phase arrest, and promote pro-apoptotic factors, which lead to cell death.

中文翻译：

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克霉唑作为抗癌药：简短回顾。

尽管克霉唑是最先用于抵抗真菌感染的药物，但后来开展了一项研究，表明该药物也具有抗癌特性。作用机理基于线粒体结合的糖酵解酶和钙调蛋白的抑制，这使癌细胞缺乏能量。克霉唑及其衍生物已显示出降低癌细胞增殖的速率，诱导G1期阻滞并促进促凋亡因子，从而导致细胞死亡。