The aim of this study was to determine whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to Behcet's disease (BD). A meta-analysis was conducted, examining the associations between the IL-10 - 1082 G/A, - 819 C/T, and - 592 C/A polymorphisms and BD in various ethnic groups. Fourteen studies involving 5992 patients and 8966 controls were considered in the meta-analysis. Meta-analysis of the IL-10 - 1082 G/A polymorphism showed no association between BD and the - 1082 G allele (odds ratio (OR) = 0.951, 95% confidence interval (CI) = 0.790-1.146, p = 0.601). Meta-analysis of the IL-10 - 819 C/T polymorphism revealed a significant association between BD and the - 819 C allele (OR = 0.751, 95% CI = 0.684-0.825, p < 0.001) in all study subjects. Stratification by ethnicity indicated a significant association between the - 819 C allele and BD in Turkish (OR = 0.779, 95% CI = 0.709-0.856, p < 0.001) and Asian (OR = 0.676, 95% CI = 0.631-0.725, p < 0.001), but not in Middle Eastern populations. Meta-analysis of the - 592 C allele showed an association with BD in all study subjects (OR = 0.792, 95% CI = 0.662-0.948, p = 0.011) Stratification by ethnicity indicated a significant association between the - 592 C allele and BD in Asian populations (OR = 0.656, 95% CI = 0.512-0.841, p = 0.001). This meta-analysis showed that the IL-10 - 819 C/T and - 592 C/A polymorphisms are associated with BD susceptibility, especially in Asian population.

中文翻译：

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对白介素10基因多态性与贝塞特氏病易感性之间关联的Meta分析。

这项研究的目的是确定白介素10（IL-10）多态性是否与对白塞氏病（BD）的易感性相关。进行了荟萃分析，研究了不同种族的IL-10-1082 G / A，-819 C / T和-592 C / A多态性与BD之间的关联。荟萃分析考虑了14项研究，涉及5992名患者和8966名对照。对IL-10-1082 G / A多态性的荟萃分析显示BD与-1082 G等位基因之间没有关联（几率（OR）= 0.951，95％置信区间（CI）= 0.790-1.146，p = 0.601） 。对所有研究对象中IL-10-819 C / T多态性的荟萃分析显示，BD与-819 C等位基因之间存在显着关联（OR = 0.751，95％CI = 0.684-0.825，p <0.001）。按种族分层显示，土耳其文（OR = 0.779，95％CI = 0.709-0.856，p <0.001）和亚洲人（OR = 0.676，95％CI = 0.631-0.725，p）-819 C等位基因与BD之间存在显着相关性<0.001），但在中东人群中没有。对所有研究对象中-592 C等位基因的荟萃分析显示与BD相关（OR = 0.792，95％CI = 0.662-0.948，p = 0.011）按种族分层表明-592 C等位基因与BD之间存在显着关联在亚洲人群中（OR = 0.656，95％CI = 0.512-0.841，p = 0.001）。这项荟萃分析表明，IL-10-819 C / T和-592 C / A多态性与BD易感性有关，尤其是在亚洲人群中。但不在中东人口中。对所有研究对象中-592 C等位基因的荟萃分析显示与BD相关（OR = 0.792，95％CI = 0.662-0.948，p = 0.011）按种族分层表明-592 C等位基因与BD之间存在显着关联在亚洲人群中（OR = 0.656，95％CI = 0.512-0.841，p = 0.001）。这项荟萃分析表明，IL-10-819 C / T和-592 C / A多态性与BD易感性有关，尤其是在亚洲人群中。但不在中东人口中。对所有研究对象中-592 C等位基因的荟萃分析显示与BD相关（OR = 0.792，95％CI = 0.662-0.948，p = 0.011）按种族分层表明-592 C等位基因与BD之间存在显着关联在亚洲人群中（OR = 0.656，95％CI = 0.512-0.841，p = 0.001）。这项荟萃分析显示，IL-10-819 C / T和-592 C / A多态性与BD易感性有关，尤其是在亚洲人群中。