The Veterans Aging Cohort Study (VACS) Index has been associated with HIV-associated neurocognitive disorder (HAND) in some populations but has not been studied in sub-Saharan Africa. We investigated whether the VACS Index is associated with HAND in a rural population in Rakai, Uganda. HIV-infected (HIV+) adults on antiretroviral therapy underwent a neurocognitive battery for determination of HAND stage using Frascati criteria. VACS component scores were recorded for all participants. Out of 156 study participants, HAND stages were 49% normal cognition, 15% asymptomatic neurocognitive impairment, 31% minor neurocognitive disorder, and 7% HIV-associated dementia. There was no significant association between VACS Index and any HAND stage. In this first study of the VACS Index in sub-Saharan Africa, we found no association between VACS Index score and HAND.

中文翻译：

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乌干达退伍军人老龄化队列研究指数与HIV相关的神经认知障碍无关。

退伍军人老龄队列研究（VACS）指数在某些人群中与HIV相关的神经认知障碍（HAND）相关，但在撒哈拉以南非洲尚未进行过研究。我们调查了乌干达拉凯市农村人口中VACS指数是否与HAND相关。接受抗逆转录病毒治疗的受HIV感染（HIV +）的成年人接受了神经认知检查，以弗拉斯卡蒂（Frascati）标准确定HAND阶段。记录所有参与者的VACS组件分数。在156名研究参与者中，HAND分期为49％正常认知，15％无症状神经认知障碍，31％轻度神经认知障碍和7％HIV相关痴呆。VACS指数与任何HAND阶段之间均无显着关联。在对撒哈拉以南非洲地区VACS指数的首次研究中，