Cerebral blood flow (CBF) assessment is mainly performed by scintigraphy, computed tomography (CT) and magnetic resonance imaging (MRI). New approaches to assess the CBF through the passage of magnetic nanoparticles (MNPs) to blood-brain barrier (BBB) are convenient to help decrease the use of ionizing radiation and unleash the required MRI schedule in clinics. The development of nanomedicine and new biomedical devices, such as the magnetic particle imaging (MPI), enabled new approaches to study dynamic brain blood flow. In this paper, we employed MNPs and the alternating current biosusceptometry (ACB) to study the brain perfusion. We utilized the mannitol, before the MNPs, injection to modulate the BBB permeability and study its effects on the circulation time of the MNPs in the brain of rats. Also, we characterized a new ACB sensor to increase the systems’ applicability to study the MNPs’ accumulation, especially in the animals’ brain. Our data showed that the injection of mannitol increased the circulation time of MNPs in the brain. Also, the mannitol increased the accumulation of MNPs in the brain. This paper suggests the use of the ACB as a tool to study brain perfusion and accumulation of MNPs in studies of new nano agents focused on the brain diagnostics and treatment.

中文翻译：

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动态脑灌注参数和磁性纳米粒子积累通过交流电生物磁法进行评估。

脑血流（CBF）评估主要通过闪烁显像，计算机断层扫描（CT）和磁共振成像（MRI）进行。通过将磁性纳米颗粒（MNP）传递到血脑屏障（BBB）来评估CBF的新方法很方便，可帮助减少电离辐射的使用并释放临床所需的MRI时间表。纳米医学和新生物医学设备的发展，例如磁性粒子成像（MPI），使得研究动态脑血流的新方法成为可能。在本文中，我们采用了MNPs和交流生物电法（ACB）来研究脑灌注。我们在MNPs注射之前利用甘露醇来调节BBB渗透性，并研究其对MNPs在大鼠脑中循环时间的影响。也，我们对新型ACB传感器进行了表征，以提高系统对MNP积累（特别是在动物大脑中）的研究的适用性。我们的数据表明，甘露醇的注射增加了MNP在大脑中的循环时间。而且，甘露醇增加了脑中MNP的积累。本文建议使用ACB作为研究脑灌注和MNP积累的工具，用于研究专注于脑诊断和治疗的新型纳米药物。