The National Toxicology Program tested two common radiofrequency radiation (RFR) modulations emitted by cellular telephones in a 2-year rodent cancer bioassay that included interim assessments of additional animals for genotoxicity endpoints. Male and female Hsd:Sprague Dawley SD rats and B6C3F1/N mice were exposed from Gestation day 5 or Postnatal day 35, respectively, to code division multiple access (CDMA) or global system for mobile modulations over 18 hr/day, at 10-min intervals, in reverberation chambers at specific absorption rates of 1.5, 3, or 6 W/kg (rats, 900 MHz) or 2.5, 5, or 10 W/kg (mice, 1,900 MHz). After 19 (rats) or 14 (mice) weeks of exposure, animals were examined for evidence of RFR-associated genotoxicity using two different measures. Using the alkaline (pH > 13) comet assay, DNA damage was assessed in cells from three brain regions, liver cells, and peripheral blood leukocytes; using the micronucleus assay, chromosomal damage was assessed in immature and mature peripheral blood erythrocytes. Results of the comet assay showed significant increases in DNA damage in the frontal cortex of male mice (both modulations), leukocytes of female mice (CDMA only), and hippocampus of male rats (CDMA only). Increases in DNA damage judged to be equivocal were observed in several other tissues of rats and mice. No significant increases in micronucleated red blood cells were observed in rats or mice. In conclusion, these results suggest that exposure to RFR is associated with an increase in DNA damage. Environ. Mol. Mutagen. 61:276-290, 2020. © 2019 Wiley Periodicals, Inc.

中文翻译：

---

亚慢性暴露后雄性和雌性大鼠和小鼠手机射频辐射遗传毒性的评估。

国家毒理学计划在为期 2 年的啮齿动物癌症生物测定中测试了蜂窝电话发出的两种常见射频辐射 (RFR) 调制，其中包括对其他动物的基因毒性终点的中期评估。雄性和雌性 Hsd:Sprague Dawley SD 大鼠和 B6C3F1/N 小鼠分别从妊娠第 5 天或产后第 35 天暴露于码分多址 (CDMA) 或全球移动调制系统超过 18 小时/天，温度为 10-分钟间隔，在混响室中，比吸收率为 1.5、3 或 6 W/kg（大鼠，900 MHz）或 2.5、5 或 10 W/kg（小鼠，1,900 MHz）。暴露 19 周（大鼠）或 14 周（小鼠）后，使用两种不同的方法检查动物是否存在 RFR 相关遗传毒性的证据。使用碱性（pH > 13）彗星试验，评估了来自三个脑区的细胞、肝细胞和外周血白细胞的 DNA 损伤；使用微核测定，评估未成熟和成熟外周血红细胞的染色体损伤。彗星试验的结果显示，雄性小鼠的额叶皮层（两种调节）、雌性小鼠的白细胞（仅限 CDMA）和雄性大鼠的海马体（仅限 CDMA）的 DNA 损伤显着增加。在大鼠和小鼠的其他几种组织中也观察到了被认为是模棱两可的 DNA 损伤的增加。在大鼠或小鼠中没有观察到微核红细胞的显着增加。总之，这些结果表明暴露于 RFR 与 DNA 损伤的增加有关。环境。摩尔。诱变剂。61:276-290, 2020。© 2019 Wiley periodicals, Inc.