Scaffolds with controlled drug release are valuable for bone tissue engineering, but constructing the scaffolds with controllable dual-drug release behaviors is still a challenge. In this study, layered mesoporous bioactive glass/sodium alginate-sodium alginate (MBG/SA-SA) scaffolds with controllable dual-drug release behaviors were fabricated by 3D printing. The porosity and compressive strength of three-dimensional (3D) printed MBG/SA-SA scaffolds by cross-linking are about 78% and 4.2 MPa, respectively. As two model drugs, bovine serum albumin (BSA) and ibuprofen (IBU) were separately loaded in SA layer and MBG/SA layer, resulting in a relatively fast release of BSA and a sustained release of IBU. Furthermore, layered MBG/SA-SA scaffolds were able to stimulate human bone mesenchymal stem cells (hBMSCs) adhesion, proliferation and osteogenic differentiation than SA scaffolds. Hence, the 3D printed MBG/SA-SA scaffolds would be prospective for the treatment of bone defects.

中文翻译：

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具有可控双重药物释放行为的层状介孔生物活性玻璃/海藻酸钠-海藻酸钠支架的3D打印。

具有受控药物释放的支架对于骨组织工程是有价值的，但是构建具有可控双重药物释放行为的支架仍然是一个挑战。在这项研究中，通过3D打印制造了具有可控双重药物释放行为的层状介孔生物活性玻璃/海藻酸钠-海藻酸钠（MBG / SA-SA）支架。通过交联的三维（3D）打印的MBG / SA-SA支架的孔隙率和抗压强度分别约为78％和4.2 MPa。作为两种模型药物，牛血清白蛋白（BSA）和布洛芬（IBU）分别装载在SA层和MBG / SA层中，导致BSA的释放相对较快，而IBU则持续释放。此外，分层的MBG / SA-SA支架能够刺激人骨间充质干细胞（hBMSC）粘附，增生和成骨分化比SA支架。因此，3D打印的MBG / SA-SA支架将有望用于治疗骨缺损。