ABSTRACT Executive functions are compromised in children with sickle cell anemia. There is limited research on the development of executive functions in preschool children with sickle cell anemia and the factors that contribute to executive dysfunction. We looked at the relation between biomedical and environmental factors, including family functioning and socioeconomic status, and executive functions in 22 preschool children with sickle cell anemia. We found that family functioning was the strongest predictor of executive outcomes in young children with sickle cell anemia with no evidence for an influence of disease severity at this early stage.

中文翻译：

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家庭功能在镰状细胞贫血学龄前儿童执行功能发展中的作用

摘要 镰状细胞性贫血儿童的执行功能受到损害。关于镰状细胞性贫血学龄前儿童执行功能的发展以及导致执行功能障碍的因素的研究有限。我们研究了 22 名患有镰状细胞性贫血的学龄前儿童的生物医学和环境因素之间的关系，包括家庭功能和社会经济地位以及执行功能。我们发现家庭功能是镰状细胞性贫血幼儿执行结果的最强预测因素，没有证据表明在这个早期阶段疾病严重程度有影响。