Heterogeneity in tumour cell properties underlies many treatment failures. Understanding the sources of such heterogeneity has proved to be challenging, but remains critical to improving patient outcomes. Integrin α(v)β₃ expression in multiple types of solid tumour stem cells is now shown to control a pro-survival pathway that contributes to therapy resistance.

中文翻译：

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整合素 β3 将治疗耐药性和癌症干细胞特性联系起来。

肿瘤细胞特性的异质性是许多治疗失败的基础。了解这种异质性的来源已被证明具有挑战性，但对于改善患者预后仍然至关重要。整合素 α(v)β₃ 在多种类型的实体瘤干细胞中的表达现在被证明可以控制导致治疗抵抗的促存活途径。