This paper presents the development of a novel micro drill device for single living organisms. Currently, microinjection for mice and some other species is performed with the help of piezo-driven actuators with a very small amount of mercury column in the proximal end of the pipette in order to increase the success rate. However, the toxicity of mercury exhibits a risk factor both for the operator and the injected cells. Therefore, mercury-free devices have become a necessity. Here, a novel micro drill is developed based on the same principle of Ros-Drill^Ⓒ piercing approach; piercing via rotational movements. The new drill is driven by a brushless motor, and it incorporates the micropipette holder. Both the amplitude and the frequency of rotational oscillations can be adjusted in very wide ranges. The experiments reveal that the drill is suitable for different tasks such as microinjection and biopsy of different organisms. It presents good performance in terms of success rate, ease of usage, compactness and compatibility with different manipulation systems.

中文翻译：

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基于Ros-DrillⒸ的新型微钻设计。

本文介绍了一种针对单一生物的新型微钻设备的开发。当前，借助于压电驱动的执行器对小鼠和其他一些物种进行显微注射，该执行器在移液管的近端具有少量的汞柱，以提高成功率。但是，汞的毒性对操作者和注入的细胞均显示出危险因素。因此，无汞设备已成为必需。在这里，基于Ros-Drill ^same的相同原理开发了一种新型的微钻刺穿方法 通过旋转运动穿刺。新钻头由无刷电机驱动，并装有微量移液器支架。旋转振动的幅度和频率都可以在很宽的范围内调节。实验表明，该钻适用于不同的任务，例如显微注射和不同生物的活检。在成功率，易用性，紧凑性以及与不同操纵系统的兼容性方面，它表现出良好的性能。