Blood viscosity measurements are crucial for the diagnosis and understanding of a range of hematological and cardiovascular diseases. Such measurements are heavily used in monitoring patients during and after surgeries, which necessitates the development of a highly accurate viscometer that uses a minimal amount of blood. In this work, we have designed and implemented a microfluidic device that was used to measure fluid viscosity with a high accuracy using less than 10 μl of blood. The device was further used to construct a blood viscosity model based on temperature, shear rate, and anti-coagulant concentration. The model has an R-squared value of 0.950. Finally, blood protein content was changed to simulate diseased conditions and blood viscosity was measured using the device and estimated using the model constructed in this work. Simulated diseased conditions were clearly detected when comparing estimated viscosity values using the model and the measured values using the device, proving the applicability of the setup in the detection of rheological anomalies and in disease diagnosis.

中文翻译：

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基于微流体的血液粘度测量装置及其基于剪切速率，温度和肝素浓度的建模。

血液粘度测量对于诊断和理解一系列血液和心血管疾病至关重要。这种测量被大量用于在手术期间和之后监测患者，这需要开发使用最少血液的高精度粘度计。在这项工作中，我们设计并实现了一种微流体设备，该设备用于使用少于10μl的血液高精度地测量流体粘度。该设备还用于根据温度，剪切速率和抗凝剂浓度构建血液粘度模型。该模型的R平方值为0.950。最后，更改血液蛋白含量以模拟疾病状况，并使用该设备测量血液粘度并使用本工作中构建的模型进行估算。