It is now becoming clear that less differentiated naive and memory T cells are superior to effector T cells in the transfer of immunity for adoptive cell therapy. This review will outline the challenges faced by chimeric antigen receptor (CAR) T cell therapy in the generation of persistence and memory for CAR T cells, and summarize recent strategies to improve CAR T cell persistence, with a focus on memory cell formation. The relevance of enhancing persistence in more differentiated effector T cells is also covered, because genetic and pharmacological interventions may prolong effector T cell activity and lifespan, thereby improving anti-cancer activity. In particular, it may be possible to enforce epigenetic changes in differentiated T cells to enhance memory CAR T cell formation. Optimizing the generation of self-renewing T cell populations (e.g. memory cells), while maintaining differentiated effector T cells through epigenome modification, will help overcome barriers to T cell expansion and survival, thereby improving clinical outcomes in CAR T cell therapy.

中文翻译：

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嵌合抗原受体T细胞的持久性和记忆细胞的形成。

现在变得清楚的是，在过继细胞疗法的免疫转移中，分化较差的天然和记忆T细胞优于效应T细胞。这篇综述将概述嵌合抗原受体（CAR）T细胞疗法在产生CAR T细胞的持久性和记忆力方面所面临的挑战，并概述提高CAR T细胞持久性的最新策略，重点是记忆细胞的形成。由于遗传和药理学干预可以延长效应T细胞的活性和寿命，从而提高抗癌活性，因此还涉及了增强在更分化的效应T细胞中持久性的相关性。特别地，有可能在分化的T细胞中强制表观遗传改变以增强记忆CAR T细胞的形成。优化自我更新T细胞群体的产生（例如