Convergent lines of evidence indicate the critical roles of adiponectin in regulating neural functions on different levels. Because of the importance in maintaining neural plasticity including adult neurogenesis and synaptic plasticity, adiponectin has the potential to serve as the treatment targets in therapies of neurological and psychiatric disorders. Hence, systematic review is needed to summarize how adiponectin works in the brain, and how the adiponectin pathway is employed as the treatment method needs to be determined. Moreover, the benefits of adiponectin as the regulator for neural plasticity such as synaptic plasticity and neurogenesis have been supported by many literatures. In the current article, we reviewed the functions of adiponectin in different types of neural plasticity. We also demonstrated the potential value of adiponectin as the treatment target for different types of neurodegenerative and psychiatric disorders. Taken together, this review offers a new insight about adiponectin as the ideal target to develop the new treatment methods against neurodegeneration or psychiatric diseases.

中文翻译：

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脂联素信号在调节神经可塑性中的作用及其作为神经精神疾病治疗靶点的应用

趋同的证据表明脂联素在不同水平调节神经功能中的关键作用。由于在维持神经可塑性（包括成人神经发生和突触可塑性）方面的重要性，脂联素有可能成为神经和精神疾病治疗的治疗靶点。因此，需要系统回顾总结脂联素如何在大脑中发挥作用，以及脂联素途径如何作为治疗方法需要确定。此外，脂联素作为神经可塑性调节剂（如突触可塑性和神经发生）的益处已得到许多文献的支持。在本文中，我们回顾了脂联素在不同类型神经可塑性中的作用。我们还展示了脂联素作为不同类型神经退行性和精神疾病治疗靶点的潜在价值。总之，本综述提供了关于脂联素作为开发针对神经退行性疾病或精神疾病的新治疗方法的理想靶标的新见解。