The cultural impact of rabies, the fatal neurological disease caused by infection with rabies virus, registers throughout recorded history. Although rabies has been the subject of large-scale public health interventions, chiefly through vaccination efforts, the disease continues to take the lives of about 40,000-70,000 people per year, roughly 40% of whom are children. Most of these deaths occur in resource-poor countries, where lack of infrastructure prevents timely reporting and postexposure prophylaxis and the ubiquity of domestic and wild animal hosts makes eradication unlikely. Moreover, although the disease is rarer than other human infections such as influenza, the prognosis following a bite from a rabid animal is poor: There is currently no effective treatment that will save the life of a symptomatic rabies patient. This review focuses on the major unanswered research questions related to rabies virus pathogenesis, especially those connecting the disease progression of rabies with the complex dysfunction caused by the virus in infected cells. The recent applications of cutting-edge research strategies to this question are described in detail.

中文翻译：

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您一直想知道的有关狂犬病病毒的所有信息（但是不敢问）。

狂犬病的文化影响是由狂犬病毒感染引起的致命性神经疾病，在整个记录的历史中都有记载。尽管狂犬病已成为大规模公共卫生干预的对象，主要通过疫苗接种努力，但该疾病每年仍使约40,000-70,000人丧生，其中约40％为儿童。这些死亡大多数发生在资源贫乏的国家，那里缺乏基础设施阻碍了及时报告和暴露后预防，而且家畜和野生动物宿主的普遍存在使得根除的可能性不大。此外，尽管这种疾病比流行性感冒等其他人类感染更为罕见，但被狂犬病叮咬后的预后很差：目前尚无有效的治疗方法可以挽救有症状狂犬病患者的生命。这篇综述重点关注与狂犬病病毒发病机理有关的主要未解决的研究问题，尤其是那些将狂犬病的疾病进展与病毒在感染细胞中引起的复杂功能障碍联系起来的问题。详细介绍了前沿研究策略在此问题上的最新应用。