Analyses of xenobiotics in human tissues are used to screen individuals whose habits or environments put them at high risk of overexposure, for the surveillance of exposure patterns over time and between places, and as part of research to identify the sources and pathways of exposure in a population. Both study goals and technical considerations should guide the choice of which xenobiotics to sample and in which tissues. Understanding the absorption and distribution of the specific compound to be measured is essential to the choice of when to sample and how to interpret results. Laboratory quality is of major concern. A particular issue in the statistical treatment of results are those near to the laboratory's detection limit. Theoretical concepts are discussed in the context of studies of xenobiotic exposure among eaters of Great Lakes and St. Lawrence River sport fish.

中文翻译：

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使用生物标记来表征大湖和圣劳伦斯河鱼类食用者中的污染物暴露。

对人体组织中的异源生物进行分析可用于筛选其习惯或环境使他们有过度暴露的高风险的个人，以监测一段时间内和不同地点之间的暴露模式，并作为研究工作的一部分，以识别人体中暴露的来源和途径。人口。研究目标和技术考虑都应指导选择哪种异生物素以及在哪些组织中进行选择。了解要测量的特定化合物的吸收和分布对于选择何时采样以及如何解释结果至关重要。实验室质量是主要问题。结果的统计处理中的一个特殊问题是那些接近实验室检测极限的问题。理论概念是在大湖区和圣约翰湖食用者异种生物接触研究的背景下讨论的。