Bioorthogonal chemical reactions are paving the way for new innovations in biology. These reactions possess extreme selectivity and biocompatibility, such that their participating reagents can form covalent bonds within richly functionalized biological systems--in some cases, living organisms. This tutorial review will summarize the history of this emerging field, as well as recent progress in the development and application of bioorthogonal copper-free click cycloaddition reactions.

中文翻译：

---

化学生物学中的无铜点击环加成反应。

生物正交化学反应正在为生物学的新创新铺平道路。这些反应具有极高的选择性和生物相容性，因此它们的参与试剂可以在功能丰富的生物系统中形成共价键 - 在某些情况下，生物体。本教程回顾将总结这一新兴领域的历史，以及生物正交无铜点击环加成反应的开发和应用的最新进展。