Long-term neurocognitive and functional impairments following West Nile virus (WNV) disease are poorly understood. We assessed quality-of-life indices and neurocognitive performance in a cohort of 54 persons recovering from one of three WNV disease syndromes (fever [WNF], meningitis [WNM], or encephalitis [WNE]) approximately 1.5 years following acute illness. We compared findings between the three syndromic groups; the study cohort and a demographically similar group of 55 controls from a study of chronic fatigue syndrome (CFS); and the study cohort and a 'normative' control population based on cognitive test data. Persistent symptoms, diminished quality of life, and functional impairment were reported by 50% of WNF patients, and 75% each of WNM and WNE patients. Overall, objective neurocognitive performance did not differ significantly between the three syndromic groups, or between the study cohort and the CFS controls or the normative controls. In some neurocognitive subtests, the study cohort scored below the 15th percentile when compared with normative control data. Most persons who returned to independent living following hospitalization for WNV illness had persistent subjective complaints, but had normal cognitive function. However, a minority displayed subtle neurocognitive deficits more than 18 months following acute disease.

中文翻译：

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从西尼罗河病毒病中康复的人的神经认知和功能结局。

对西尼罗河病毒（WNV）疾病后的长期神经认知和功能损害知之甚少。我们评估了在急性疾病后约1.5年内从三种WNV疾病综合征（发烧[WNF]，脑膜炎[WNM]或脑炎[WNE]）中恢复的54名患者的生活质量指数和神经认知能力。我们比较了三个症状组之间的发现；该研究队列和人口统计学相似的一组来自慢性疲劳综合征（CFS）研究的55名对照组；以及研究群组和基于认知测试数据的“规范”对照人群。据报道，有50％的WNF患者持续出现症状，生活质量下降和功能受损，而WNM和WNE患者各占75％。总体，三个症状组之间，研究队列与CFS对照或规范对照之间的客观神经认知表现没有显着差异。在一些神经认知子测验中，与正常对照数据相比，该研究队列的得分低于第15个百分点。大多数因西尼罗病毒病住院治疗后返回独立生活的人主观症状持续存在，但认知功能正常。然而，少数人在急性疾病后超过18个月表现出微妙的神经认知缺陷。大多数因西尼罗病毒病住院治疗后返回独立生活的人持续存在主观主诉，但认知功能正常。但是，少数人在急性疾病后超过18个月表现出微妙的神经认知功能障碍。大多数因西尼罗病毒病住院治疗后返回独立生活的人持续存在主观主诉，但认知功能正常。但是，少数人在急性疾病后超过18个月表现出微妙的神经认知功能障碍。