Purposes

To identify and synthesize RCTs on the isolated effect of dosage parameters of upper limb Intensive Motor Rehabilitation Treatments (IMRT) of children with Unilateral Spastic Cerebral Palsy (USCP); to identify the most frequent methodological weaknesses.

Methods

Searches were conducted until September 2018 in gray and published literature databases and supplemented by exploring the identified studies’ references. Inclusion criteria applied: RCT; children aged 1.5 to 19 years with USCP; upper limb IMRT differing only from ≥1/4 dosage parameters between groups. Literature analyses conducted: qualitative and descriptive.

Results

We identified 461 studies. Seventeen were included: three presented a rehabilitation dosage distinction between groups in Frequency-Time, four in Intensity-Progressivity, three in Intensity-Restraint, two in Intensity-Environment and five presented ≥3 distinctions above.

Conclusions

Inconsistencies were noted between USCP lifelong issues, and the short follow-ups and lack of participation assessments. Confounding factors and misstatements in Intent To Treat (ITT) analyses were identified. A meta-analysis was considered irrelevant.

Abbreviations

USCP, CP: Unilateral Spastic Cerebral Palsy, Cerebral Palsy; RCT: Randomized Controlled Trial; IMRT: Intensive Motor Rehabilitation Treatment

中文翻译：

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对单侧痉挛性脑瘫儿童进行强化上肢康复剂量参数研究的方法学考虑：RCT的研究范围。

目的

鉴定和合成对单侧痉挛性脑瘫（USCP）患儿上肢强化运动康复治疗（IMRT）剂量参数的孤立作用的RCT；找出最常见的方法学缺陷。

方法

搜索在2018年9月之前在灰色和已出版的文献数据库中进行，并通过探索确定的研究参考文献进行补充。适用的纳入标准：RCT；1.5至19岁的USCP儿童；两组之间的上肢IMRT仅与≥1/4剂量参数不同。进行的文献分析：定性和描述性。

结果

我们确定了461项研究。其中包括十七个：三个代表频率-时间组之间的康复剂量区分，四个代表强度-进步性，三个代表强度-约束，两个代表强度-环境，五个代表≥3。

结论

有人指出，USCP的终身问题与后续行动短，缺乏参与评估之间存在不一致之处。确定了意图治疗（ITT）分析中的混杂因素和错误陈述。荟萃分析被认为是不相关的。

缩略语

USCP，CP：单侧痉挛性脑瘫，脑性瘫痪；RCT：随机对照试验；IMRT：强化电机康复治疗