Implant materials applied in bone defect commonly focus on the inducement of bone regeneration and neglect to cure complications including bacterial infection and inflammation, which may result in delayed unions or even amputation. In this study, a microporous silica nanoparticle‐poly(N‐isopropylacrylamide‐b‐(2‐(dimethylamino)ethyl methacrylate) is synthesized for loading DXMS and the ECM‐derived peptide (Sequence: Succinic acid‐GTPGPQGIAGQRGVV) in order to enhance the osteoblast calcification and relieve related symptoms. Positively charged PDMA blocks endow the nanoparticle with the antimicrobial property. Moreover, the combination of DXMS makes it have the ability of anti‐inflammation and promoting calcification formation. Furthermore, incorporation of the peptide leads to a significant improvement of mineralization and alkaline phosphatase expression in the preosteoblast. After intramuscular implantation in mice for four weeks, the results indicate the composite nanoparticle can promote ectopic bone formation. These combined properties make the composite silicon nanoparticle a promising osteogenic drug appropriate for further study in bone repair and related combination therapy.

中文翻译：

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设计用于增强成骨细胞钙化和相关联合治疗的多功能硅纳米粒子。

用于骨缺损的植入物材料通常集中在诱导骨再生上，而忽视了治愈包括细菌感染和炎症在内的并发症，这可能会导致延迟愈合甚至截肢。在这项研究中，微孔硅石纳米颗粒的聚（Ñ合成了异丙基丙烯酰胺-b-（甲基丙烯酸2-（二甲氨基）乙基酯）以加载DXMS和ECM衍生肽（序列：琥珀酸-GTPGPQGIAGQRGVV），以增强成骨细胞钙化并缓解相关症状。带正电的PDMA嵌段使纳米颗粒具有抗菌性能。此外，DXMS的组合使其具有抗炎和促进钙化形成的能力。此外，肽的掺入导致前成骨细胞中矿化和碱性磷酸酶表达的显着改善。小鼠肌肉内植入四个星期后，结果表明该复合纳米颗粒可促进异位骨形成。