Platelet activation plays an important role in acute and chronic cardiovascular disease states. Multiple pathways contribute to platelet activation including those dependent upon arachidonic acid. Arachidonic acid is released from the platelet membrane by phospholipase A2 action and is then metabolized in the cytosol by specific arachidonic acid oxidation enzymes including prostaglandin H synthase, 12-lipoxygenase, and cytochrome P450 to produce pro- and anti-inflammatory eicosanoids. This review aims to analyze the role of arachidonic acid oxidation on platelet activation, the enzymes that use it as a substrate associated as novel therapeutics target for antiplatelet drugs.

中文翻译：

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花生四烯酸的氧化途径作为调节血小板活化的靶标。

血小板活化在急性和慢性心血管疾病状态中起重要作用。多种途径有助于血小板活化，包括依赖于花生四烯酸的那些。花生四烯酸通过磷脂酶A2的作用从血小板膜中释放出来，然后通过特定的花生四烯酸氧化酶（包括前列腺素H合酶，12-脂加氧酶和细胞色素P450）在细胞质中代谢，从而产生促炎和抗炎的类花生酸。这篇综述旨在分析花生四烯酸氧化对血小板活化的作用，花生四烯酸氧化酶将其用作抗血小板药物的新型治疗靶标相关的底物。