Skeletal muscles are characterized by their unique regenerative capacity following injury due to the presence of muscle precursor cells, satellite cells. This characteristic allows researchers to study muscle regeneration using experimental injury models. These injury models should be stable and reproducible. Variety of injury models have been used, among which the intramuscular injection of myotoxic biotoxins is considered the most common and widespread method in muscle regeneration research. By using isolated biotoxins, researchers could induce acute muscle damage and regeneration in a controlled and reproducible manner. Therefore, it is considered an easy method for inducing muscle injury in order to understand the different mechanisms involved in muscle injuries and tissue response following injury. However, different toxins and venoms have different compositions and subsequently the possible effects of these toxins on skeletal muscle vary according to their composition. Moreover, regeneration of injured muscle by venoms and toxins varies according to the target of toxin or venom. Therefore, it is essential for researcher to be aware of the mechanism and possible target of toxin-induced injury. The current paper provides an overview of the biotoxins used in skeletal muscle research.

中文翻译：

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肌肉再生研究中的生物毒素。

骨骼肌的特征是由于肌肉前体细胞，卫星细胞的存在，在受伤后具有独特的再生能力。这一特征使研究人员可以使用实验性损伤模型研究肌肉再生。这些伤害模型应稳定且可重现。已经使用了多种损伤模型，其中肌肉内注射肌毒性生物毒素被认为是肌肉再生研究中最常用和最广泛的方法。通过使用分离的生物毒素，研究人员可以以受控和可复制的方式诱导急性肌肉损伤和再生。因此，被认为是诱发肌肉损伤的一种简便方法，以便了解涉及肌肉损伤和损伤后组织反应的不同机制。然而，不同的毒素和毒液具有不同的成分，因此这些毒素对骨骼肌的可能作用随其成分而变化。此外，毒液和毒素对受伤肌肉的再生根据毒素或毒液的目标而变化。因此，对于研究人员来说，了解毒素引起的损伤的机制和可能的靶标至关重要。本论文概述了骨骼肌研究中使用的生物毒素。