Several studies have suggested that oxidative stress might cause and aggravate the inflammatory state associated with obesity and could be the link between excessive weight gain and its related disorders such as insulin resistance and cardiovascular diseases. Thus, antioxidant treatment has been proposed as a therapy to prevent and manage obesity and associated complications. Therefore, the aim of the present study was to investigate the effects of supplementation of a standard or high fat diet with the antioxidant lipoic acid (LA) during 56 days, on body weight gain, adiposity, feed efficiency and intestinal sugar absorption, in male Wistar rats. LA supplementation induced a lower body weight gain and adipose tissue size in both control or high fat fed rats accompanied by a reduction in food intake. The group fed on a high fat diet and treated with LA (OLIP group) showed a lower body weight gain than its corresponding Pair-Fed (PF) group (P<0.05), which received the same amount of food than LA-treated animals but with no LA. In fact, LA induced a reduction on feed efficiency and also significantly decreased intestinal α-methylglucoside (α-MG) absorption both in lean and obese rats. These results suggest that the beneficial effects of dietary supplementation with LA on body weight gain are mediated, at least in part, by the reduction observed in food intake and feed efficiency. Furthemore, the inhibitory action of LA on intestinal sugar transport could explain in part the lower feed efficiency observed in LA-treated animals and therefore, highlighting the beneficial effects of LA on obesity.

中文翻译：

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硫辛酸可防止大鼠高脂肪饮食引起的体重增加：对肠道糖转运的影响。

几项研究表明，氧化应激可能会导致和加剧与肥胖相关的炎症状态，并且可能是体重过度增加与其相关疾病（如胰岛素抵抗和心血管疾病）之间的联系。因此，已经提出抗氧化治疗作为预防和管理肥胖症及相关并发症的疗法。因此，本研究的目的是研究在 56 天内添加抗氧化硫辛酸 (LA) 的标准或高脂肪饮食对雄性体重增加、肥胖、饲料效率和肠道糖吸收的影响。威斯塔老鼠。在对照组或高脂肪喂养的大鼠中，LA 补充剂导致较低的体重增加和脂肪组织大小，同时食物摄入量减少。P<0.05 )，与接受 LA 治疗但没有接受 LA 的动物接受相同量的食物。事实上，LA 导致饲料效率降低，并且还显着降低了瘦大鼠和肥胖大鼠的肠道 α-甲基葡萄糖苷 (α-MG) 吸收。这些结果表明，膳食补充剂 LA 对体重增加的有益影响至少部分是通过观察到的食物摄入量和饲料效率的降低来介导的。此外，LA 对肠道糖转运的抑制作用可以部分解释在 LA 治疗的动物中观察到的较低的饲料效率，因此，突出了 LA 对肥胖的有益影响。